Protein Information

Name Kir6.2
Synonyms ATP sensitive inward rectifier potassium channel II; ATP sensitive inward rectifier potassium channel 11; BIR; Beta cell inward rectifier subunit; HHF 2; HHF2; IKATP; Inward rectifier K(+) channel Kir6.2…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
10864893 McKay NG, Kinsella JM, Campbell CM, Ashford ML: Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K (ATP) channel inhibitors, ciclazindol and englitazone. Br J Pharmacol. 2000 Jun;130(4):857-66.
41(0,1,2,6) Details
11082117 Trapp S, Ashcroft FM: Direct interaction of Na-azide with the KATP channel. Br J Pharmacol. 2000 Nov;131(6):1105-12.

The effects of the metabolic inhibitor sodium azide were tested on excised macropatches from XENOPUS: oocytes expressing cloned ATP-sensitive potassium (KATP) channels of the Kir6.2/SUR1 type. 2.
35(0,1,1,5) Details
18678543 Kung FL, Tsai JL, Lee CH, Lou KL, Tang CY, Liou HH, Lu KL, Chen YH, Wang WJ, Tsai MC: Effects of sodium azide, barium ion, d-amphetamine and procaine on inward rectifying potassium channel 6.2 expressed in Xenopus oocytes. J Formos Med Assoc. 2008 Aug;107(8):600-8.

METHODS: The coding sequence of a truncated form of mouse Kir6.2 (GenBank accession number NP_034732.1), Kir6.2 (1-364) (i.e.
2(0,0,0,2) Details
9135131 Gribble FM, Tucker SJ, Ashcroft FM: The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J. 1997 Mar 17;16(6):1145-52.


The beta-cell K-ATP channel consists of a pore-forming subunit, Kir6.2, and a regulatory subunit, SUR1.
1(0,0,0,1) Details
10050011 Lee K, Dixon AK, Richardson PJ, Pinnock RD: Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol. 1999 Mar 1;515 ( Pt 2):439-52.


In cell-attached recordings, removal of extracellular glucose or metabolic inhibition with sodium azide reduced the firing rate of a subpopulation of cells through the activation of a 65 pS channel that was blocked by the sulphonylureas tolbutamide and glibenclamide. 2.
0(0,0,0,0) Details
9705995 Lee K, Dixon AK, Freeman TC, Richardson PJ: Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones. J Physiol. 1998 Jul 15;510 ( Pt 2):441-53.


Using permeabilized patch recordings, neurones were shown to hyperpolarize in response to glucose deprivation or metabolic poisoning with sodium azide (NaN3).
0(0,0,0,0) Details