| Name | myeloperoxidase |
|---|---|
| Synonyms | 38 kDa MYELOPEROXIDASE; MPO; Myeloperoxidase; Myeloperoxidase precursor; Peroxidase (Myeloperoxidase); Myeloperoxidases; Myeloperoxidase precursors; Peroxidase (Myeloperoxidase)s |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7923887 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB: Use of methyl prednisolone and antioxidants in mercuric chloride-induced experimental vasculitis. Clin Exp Immunol. 1994 Oct;98(1):66-70. Mercuric chloride (HgCl2) treatment induces an autoimmune syndrome and necrotizing leucocytoclastic vasculitis in the Brown Norway (BN) rat; anti-myeloperoxidase (MPO) and anti-glomerular basement (GBM) antibodies are present, and vasculitis is reduced by antimicrobials. |
31(0,1,1,1) | Details |
| 8388693 | Mathieson PW, Qasim FJ, Esnault VL, Oliveira DB: Animal models of systemic vasculitis. . J Autoimmun. 1993 Apr;6(2):251-64. We have recently reported that Brown Norway rats treated with mercuric chloride (HgCl2) develop necrotizing leucocytoclastic vasculitis, especially in the gut, and also develop antibodies to myeloperoxidase (MPO) which recognize similar determinants on MPO to those bound by a subset of ANCA. |
31(0,1,1,1) | Details |
| 1320710 | Esnault VL, Mathieson PW, Thiru S, Oliveira DB, Martin-Lockwood C: Autoantibodies to myeloperoxidase in brown Norway rats treated with mercuric chloride. Lab Invest. 1992 Jul;67(1):114-20. |
7(0,0,1,2) | Details |
| 8296602 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB, Lockwood CM: Further characterization of an animal model of systemic vasculitis. . Adv Exp Med Biol. 1993;336:133-7. The demonstration of vasculitis and anti-myeloperoxidase antibodies in the mercuric chloride treated Brown Norway rat provides a useful, though limited, animal model of systemic vasculitis. |
6(0,0,1,1) | Details |
| 7853852 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB: Cyclosporin A exacerbates mercuric chloride-induced vasculitis in the brown Norway rat. Lab Invest. 1995 Feb;72(2):183-90. BACKGROUND: Administration of mercuric chloride (HgCl2) to the Brown Norway (BN) rat induces a necrotizing leukocytoclastic vasculitis (most marked in the gut) and anti-myeloperoxidase (anti-MPO) antibodies. |
6(0,0,1,1) | Details |
| 14675463 | Sener G, Sehirli AO, Ayanoglu-Dulger G: protects against mercury (II)-induced oxidative tissue damage in rats. Pharmacol Toxicol. 2003 Dec;93(6):290-6. Tissue samples were taken for determination of malondialdehyde, an end-product of lipid peroxidation; (GSH), a key antioxidant, and myeloperoxidase activity, an index of neutrophil infiltration. Rats were intraperitoneally injected with 1) 0.9% NaCl, control (C) group; 2) a single dose of 5 mg/kg mercuric chloride (HgCl2), Hg group; 3) in a dose of 10 mg/kg, 1 hr after HgCl2 injection, Hg- group; 4) in a dose of 10 mg/kg one day before and 1 hr after HgCl2 injection, -Hg- group; 5) N- in a dose of 150 mg/kg, 1 hr after HgCl2 injection, Hg- group, and 6) in a dose of 150 mg/kg one day before and 1 hr after HgCl2 injection, -Hg- group. |
2(0,0,0,2) | Details |
| 8686765 | Qasim FJ, Mathieson PW, Sendo F, Thiru S, Oliveira DB: Role of neutrophils in the pathogenesis of experimental vasculitis. . Am J Pathol. 1996 Jul;149(1):81-9. In the Brown-Norway rat, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by high IgE levels. As in systemic vasculitis in man, there are neutrophils at the site of tissue injury and the animals develop anti-neutrophil cytoplasmic antibodies, which in the Brown-Norway rat are directed against myeloperoxidase. |
2(0,0,0,2) | Details |
| 10647949 | Specks U: Are animal models of vasculitis suitable tools? . Curr Opin Rheumatol. 2000 Jan;12(1):11-9. Specific interventions, such as the treatment of Brown Norway rats with agents resulting in polyclonal B cell stimulation or immunization with human myeloperoxidase and subsequent localized perfusion with neutrophil lysosomal extract and H2O2, have provided substantial insights into the cellular and molecular mechanisms leading to the development of vasculitis and glomerulonephritis. |
1(0,0,0,1) | Details |
| 10469269 | Harris FE, Turner DR, Oliveira DB: Early vasculitis in the mercuric chloride induced Brown Norway rat model is neutrophil independent. Int J Exp Pathol. 1999 Jun;80(3):133-42. Caecums were excised and myeloperoxidase, a marker enzyme for neutrophil infiltration, assayed. |
1(0,0,0,1) | Details |
| 11934688 | Miyaji T, Hu X, Star RA: alpha-Melanocyte-simulating hormone and interleukin-10 do not protect the kidney against mercuric chloride-induced injury. Am J Physiol Renal Physiol. 2002 May;282(5):F795-801. Animals were killed to study serum histology, and myeloperoxidase activity. |
1(0,0,0,1) | Details |
| 9182889 | Qasim FJ, Thiru S, Gillespie K: Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: support for a role for Th2 cell activity. Clin Exp Immunol. 1997 Jun;108(3):438-45. DP, gold salts and mercuric chloride (HgCl2) are known to induce Th2-dominated autoimmune syndromes in genetically susceptible rodent strains, and we have demonstrated recently that HgCl2 up-regulates messenger RNA (mRNA) for IL-4 in the Brown Norway (BN) rat. In the BN rat HgCl2 treatment is also associated with the development of vasculitis, and anti-myeloperoxidase (MPO) antibodies are found in the serum. |
1(0,0,0,1) | Details |
| 17267089 | Sener G, Sehirli O, Tozan A, Velioglu-Ovunc A, Gedik N, Omurtag GZ: Ginkgo biloba extract protects against mercury (II)-induced oxidative tissue damage in rats. Food Chem Toxicol. 2007 Apr;45(4):543-50. Epub 2006 Aug 30. Following a single dose of 5mg/kg mercuric chloride (HgCl (2); Hg group) either saline or EGb (150mg/kg) was administered for 5days. After decapitation of the rats trunk blood was obtained and the tissue samples from the brain, lung, liver, and kidney were taken for the determination of malondialdehyde (MDA) and (GSH) levels, myeloperoxidase (MPO) activity and collagen contents. |
1(0,0,0,1) | Details |
| 9853004 | Girardi G, Elias MM: protection against mercuric chloride-induced renal glomerular injury in rats. Toxicol Appl Pharmacol. 1998 Oct;152(2):360-5. pretreatment also protected glomeruli from enhanced leukocyte content (myeloperoxidase activity/mg protein): control, 59 +/- 7; HgCl2, 134 +/- 10; Vp + Hg, 79 +/- 11). |
1(0,0,0,1) | Details |
| 8918574 | Kiely PD, O'Brien D, Oliveira DB: Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996 Nov;106(2):280-5. |
0(0,0,0,0) | Details |