Protein Information

Name delta opioid receptor
Synonyms Delta type opioid receptor; Delta type opioid receptor; OPRD; OPRD 1; OPRD1; delta opioid receptor; delta1 opioid receptor; Delta type opioid receptors…

Compound Information

Name dithioether
CAS dimethyl disulfide

Reference List

PubMed Abstract RScore(About this table)
2845204 Mosberg HI, Omnaas JR, Medzihradsky F, Smith CB: Cyclic, disulfide- and dithioether-containing opioid tetrapeptides: development of a ligand with high delta opioid receptor selectivity and affinity. Life Sci. 1988;43(12):1013-20.
82(1,1,1,2) Details
3037296 Mosberg HI, Omnaas JR, Goldstein A: Structural requirements for delta opioid receptor binding. . Mol Pharmacol. 1987 Jun;31(6):599-602.

The major effect of increasing the ring size of the cyclic moiety from disulfide to dithioether analogs was a large decrease in delta opioid receptor binding affinity which suggests that relatively compact conformations of the peptide ligand are necessary for optimal binding to this receptor.
32(0,1,1,2) Details