Protein Information

Name muscles
Synonyms COX 7a M; COX VIIa M; COX7A; COX7A1; COX7A1 protein; COX7AH; COX7AM; Cytochrome c oxidase subunit 7a H…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
1665979 Komori T, Yamane K, Nagayama T, Shibata K, Nozaki H, Takeuchi M: [A case of delayed myeloneuropathy due to malathion intoxication] . No To Shinkei. 1991 Oct;43(10):969-74.

Following recovery from an acute cholinergic phase 36 hours after ingestion, respiratory muscle weakness, consciousness disturbance and diffuse weakness of the limb muscles occurred, necessitating mechanical ventilation.
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3188779 Kolesnichenko IP, Buchko VM, Vladeeva NV: [Clinico-morphologic and histochemical changes in the neuromuscular apparatus in acute carbophos poisoning]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(7):76-80.

Clinical analysis of 378 acute cases of Malathion insecticide intoxication and pathological and histochemical investigation of skeletal muscles in 7 autopsied victims of acute poisoning have revealed the pronounced neuromuscular disorders.
Generalized paresis and paralysis of muscles were observed in trunk and limbs.
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9767909 Benslama A, Moutaouakkil S, Mjahed K, el Moknia M, Lahbil D, Fadel H: [Intermediary syndrome in acute malathion poisoning] . Presse Med. 1998 Apr 18;27(15):713-5.

The intermediate syndrome is confined to an abnormality of neuromuscular function in specific muscle groups: proximal limb muscles, neck flexors, motor cranial nerves and respiratory muscles, with difficult weaning from respiratory assistance.
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16334280 Saqib TA, Naqvi SN, Siddiqui PA, Azmi MA: Detection of pesticide residues in muscles, liver and fat of 3 species of Labeo found in Kalri and Haleji lakes. J Environ Biol. 2005 Jun;26(2 Suppl):433-8.

Deltamethrin was found in 7 samples and malathion in none.
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9597208 Choi PT, Quinonez LG, Cook DJ, Baxter F, Whitehead L: The use of glycopyrrolate in a case of intermediate syndrome following acute organophosphate poisoning. Can J Anaesth. 1998 Apr;45(4):337-40.

CLINICAL FEATURES: A 44-yr-old woman presented in cholinergic crisis following malathion ingestion.
CONCLUSION: This case report describes the successful use of glycopyrrolate in organophosphate intoxication and the development of the intermediate syndrome, characterised by onset of weakness of neck flexors, proximal limb muscles, and respiratory muscles within one to four days after poisoning.
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15914239 Sapozhnikova Y, Zubcov N, Hungerford S, Roy LA, Boicenco N, Zubcov E, Schlenk D: Evaluation of pesticides and metals in fish of the Dniester River, Moldova. Chemosphere. 2005 Jul;60(2):196-205.

Among organophosphorous pesticides, malathion showed extremely high concentrations--3 microg/g wet weight in muscles and 46 microg/g wet weight in gonads, indicating recent exposure.
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19444631 Beltran KS, Pocsidio GN: Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2009 May 12.

In vitro experiments on the total soft tissue, adductor muscles, digestive glands, and gills were conducted to assess the degree of localization of AChE as well as the sensitivity and tolerance of the enzymes in these tissues to varying concentrations of malathion.
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16850888 Venkataramana GV, Rani PN, Murthy PS: Impact of malathion on the biochemical parameters of gobiid fish, Glossogobius giuris (Ham). J Environ Biol. 2006 Jan;27(1):119-22.

The cardiac muscles showed maximum depletion of glycogen and cholesterol content during 72 and 96 hr after treatment with 0.5 ppm malathion.
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3606418 Kolesnichenko IP: [Histopathology of the skeletal musculature in acute peroral carbophos poisoning]. Arkh Patol. 1987;49(4):61-7.


Clinical studies of 378 patients with acute carbophose poisoning were carried out, as well as histological studies of striated muscles (gastrocnemius, anterior tibial, intercostal and phrenic) from 7 poisoned with lethal outcome due to acute oral intake of carbophose (malation).
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1601353 Jadhav RK, Sharma VK, Rao GJ, Saraf AK, Chandra H: Distribution of malathion in body tissues and fluids. Forensic Sci Int. 1992 Jan;52(2):223-9.

The distribution of malathion was studied in lungs, liver, kidneys, spleen, brain, heart, blood, muscles, urine and gastric contents.
6(0,0,1,1) Details
15041284 Sapozhnikova Y, Bawardi O, Schlenk D: Pesticides and PCBs in sediments and fish from the Salton Sea, California, USA. Chemosphere. 2004 May;55(6):797-809.

DDE concentrations in fish muscles tissues were above the 50 ng/g concentration threshold for the protection of predatory birds.
Dimethoate, diazinon, malathion, chlorpyrifos, disulfoton varied from < or = 0.15 to 9.5 ng/g dry wt in sediments and from < or = 0.1 to 80.3 ng/g wet wt in fish tissues.
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