Protein Information

Name cathepsin D
Synonyms CATD; CLN10; CPSD; CTSD; Cathepsin D; Cathepsin D precursor; cathepsin D (lysosomal aspartyl peptidase); cathepsin D (lysosomal aspartyl protease)…

Compound Information

Name malathion
CAS diethyl 2-[(dimethoxyphosphinothioyl)thio]butanedioate

Reference List

PubMed Abstract RScore(About this table)
9306154 Rodgers K, Xiong S: Contributions of inflammatory mast cell mediators to alterations in macrophage function after malathion administration. Int J Immunopharmacol. 1997 Mar;19(3):149-56.

Intraperitoneal administration of indomethacin, and inhibitor of cycloxygenase, or neutralizing antibody to TNF 30 h before and 4 h after oral malathion blocked the ability of malathion to increase macrophage function, as measured by the generation of respiratory burst activity and the production of cathepsin D.
81(1,1,1,1) Details
8812242 Rodgers K, Xiong S: Contribution of mast cell mediators to alterations in macrophage function after malathion administration. Fundam Appl Toxicol. 1996 Sep;33(1):100-8.

Coadministration of intraperitoneal cromolyn, a stabilizer of mast cell membranes, with oral malathion blocked the ability of malathion to increase macrophage function as measured by the generation of respiratory burst activity, the phagocytosis of opsonized yeast, and the production of cathepsin D.
81(1,1,1,1) Details
9381485 Rodgers K, Xiong S: Effect of administration of malathion for 90 days on macrophage function and mast cell degranulation. Toxicol Lett. 1997 Sep 19;93(1):73-82.

In this report, the effects of malathion administration for 90 days on macrophage function, as measured by respiratory burst capacity, phagocytic capability and the production of cathepsin D, and mast cell integrity were assessed.
112(1,2,2,2) Details