| Name | sulfotransferases (protein family or complex) |
|---|---|
| Synonyms | sulfotransferase; sulfotransferases |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2401045 | Mangold BL, Erickson J, Lohr C, McCann DJ, Mangold JB: Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N--2-acetylaminofluorene. Carcinogenesis. 1990 Sep;11(9):1563-7. The inactivation was dependent and blocked by the sulfotransferase inhibitor, pentachlorophenol. |
0(0,0,0,0) | Details |
| 6257402 | Kadlubar FF, Unruh LE, Flammang TJ, Sparks D, Mitchum RK, Mulder GJ: Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine, and its N- in the rat by control of urinary pH, inhibition of metabolic sulfation, and changes in biliary excretion. Chem Biol Interact. 1981 Jan;33(2-3):129-47. Pentachlorophenol, a known inhibitor of hepatic sulfotransferases, was shown to cause a 2--3-fold increase in the urinary levels of N-HO-2-NA N- and N-HO-2-NA from 2-NA-treated rats. |
81(1,1,1,1) | Details |
| 2480190 | van de Poll ML, Tijdens RB, Vondracek P, Bruins AP, Meijer DK, Meerman JH: The role of sulfation in the metabolic activation of N--4'--4-acetylaminobiphenyl. Carcinogenesis. 1989 Dec;10(12):2285-91. N-OH-FAABP was a substrate for sulfotransferases in vitro and sulfation was inhibited by the sulfotransferase inhibitors pentachlorophenol (PCP) and 2,6-dichloro- (DCNP). |
81(1,1,1,1) | Details |
| 9485541 | Daimon H, Sawada S, Asakura S, Sagami F: Inhibition of sulfotransferase affecting in vivo genotoxicity and DNA adducts induced by in rat liver. Teratog Carcinog Mutagen. 1997-1998;17(6):327-37. The effect of pretreatment with pentachlorophenol (PCP), a known inhibitor of sulfotransferases, on the induction of chromosomal aberrations, sister chromatid exchanges (SCEs), replicative DNA synthesis (RDS), and the formation of DNA adducts was studied in the liver of rats treated with (1-allyl-3,4-methylenedioxy- |
81(1,1,1,1) | Details |
| 15975044 | Tsoi C, Swedmark S: Sulfation in dog. Curr Drug Metab. 2005 Jun;6(3):275-85. Stereoselectivity, inhibition by pentachlorophenol, bioactivation of DNA binding species, and gender differences have also been observed for canine sulfotransferases (SULTs). |
81(1,1,1,1) | Details |
| 9566752 | Visser TJ, Kaptein E, Glatt H, Bartsch I, Hagen M, Coughtrie MW: Characterization of thyroid hormone sulfotransferases. . Chem Biol Interact. 1998 Feb 20;109(1-3):279-91. Different derivatives were found to be potent inhibitors of the sulfation of 3,3'-T2 by native and recombinant sulfotransferases, with pentachlorophenol and 2,4,6-tribromophenol being the most potent. |
31(0,1,1,1) | Details |
| 10773360 | Boles JW, Klaassen CD: Effects of and pentachlorophenol on the sulfation of Toxicology. 2000 Apr 20;146(1):23-35. These data indicate that PCP is more effective in decreasing the sulfation of low than high doses of AA, which may result from less AA, at lower doses, to compete with PCP for sulfotransferases. |
2(0,0,0,2) | Details |
| 9827058 | Finnson KW, Eales JG: Sulfation of thyroid hormones by liver of rainbow trout, Oncorhynchus mykiss. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1998 Oct;120(3):415-20. Inhibitor profiles for both T4- and T3-sulfation were not significantly different with a common inhibitor preference of rT3 > pentachlorophenol > triiodothyroacetic acid > tetraiodothyroacetic acid T4 = T3 = We conclude that: (i) in trout, hepatic sulfation of TH is enzymatic and obeys Michaelis-Menten kinetics; (ii) like mammalian hepatic sulfotransferases (STs), trout hepatic STs are heat-sensitive cytosolic proteins using as a donor; (iii) unlike mammalian sulfation of TH, trout hepatic sulfation of T4, T3 and rT3 may be catalyzed by a single form of ST preferring rT3 as substrate and with a catalytic efficiency of rT3 >>> T3 > T4. |
1(0,0,0,1) | Details |
| 14695936 | Chan TS, O'Brien PJ: Hepatocyte metabolism of to its conjugate decreases its antioxidant activity. Biofactors. 2003;18(1-4):207-18. Sulfotransferases may therefore play a significant role in endogenous metabolism following its degradation to short chain products. CoQ1 conjugate formation catalysed by cytosol was inhibited by the sulfotransferase 1A (SULT1A) inhibitor, pentachlorophenol (PCP) suggesting that sulfation was carried out by the SULT 1A isoform. |
1(0,0,0,1) | Details |
| 16454694 | Wang LQ, James MO: Inhibition of sulfotransferases by xenobiotics. Curr Drug Metab. 2006 Jan;7(1):83-104. SULT activity may be inhibited when humans are exposed to certain xenobiotics including drugs (mefenamic acid, clomiphene, danazol etc.), dietary chemicals (catechins, food colorants, flavonoids and phytoestrogens etc.), and environmental chemicals (hydroxylated polychlorinated biphenyls, hydroxylated polyhalogenated aromatic hydrocarbons, pentachlorophenol, triclosan and bisphenol A, etc.). |
1(0,0,0,1) | Details |
| 6594138 | Singer SS, Ansel AZ, Van Brunt N, Torres J, Galaska EG: Enzymatic sulfation of steroids--XX. Biochem Pharmacol. 1984 Nov 1;33(21):3485-90. The enzyme activity per 100 g body weight was elevated 152, 94.9, 140, 140, 73.1, 63.9, 76.9, and 140% after administration of daily i.p. doses of 111 mg spironolactone/kg (6-10 days), 66.7 mg WIN-24540/kg (6-10 days), 150 mg /kg (19-31 days), 33.3 mg pentachlorophenol/kg (9-16 days), 16.5 mg /kg (10-16 days), 90.5 mg /kg (23.27 days), 104 mg aminoglutethimide/kg (12-20 days), and 16.8 mg /kg (21-27 days). Effects of the other test drugs were due to elevation of hepatic levels of sulfotransferases I and II (STI and STII), which much prefer as substrate, but also catalyze glucocorticoid sulfation. |
1(0,0,0,1) | Details |
| 8055653 | Kaderlik KR, Mulder GJ, Shaddock JG, Casciano DA, Teitel CH, Kadlubar FF: Effect of depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes. Carcinogenesis. 1994 Aug;15(8):1711-6. Pentachlorophenol, which strongly inhibits sulfotransferases, decreased adduct formation slightly, but had essentially no effect on UDS or on the formation of PhIP metabolites. |
0(0,0,0,0) | Details |