Protein Information

Name hydroxysteroid sulfotransferases
Synonyms Alcohol sulfotransferase; ST2; Estrogen sulfotransferase; Alcohol/hydroxysteroid sulfotransferase; Bile salt sulfotransferase; DHEA sulphotransferase; DHEA ST; Dehydroepiandrosterone sulfotransferase…

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
18656962 Gulcan HO, Liu Y, Duffel MW: Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol. 2008 Aug;21(8):1503-8. Epub 2008 Jul 26.
82(1,1,1,2) Details
9705892 Boles JW, Klaassen CD: Effects of molybdate and pentachlorophenol on the sulfation of dehydroepiandrosterone. Toxicol Appl Pharmacol. 1998 Jul;151(1):105-9.

Therefore, it was of interest to determine whether PCP or molybdate is effective in decreasing the in vivo sulfation of dehydroepiandrosterone (DHEA), which is a substrate for hydroxysteroid-sulfotransferases.
2(0,0,0,2) Details
1824923 Surh YJ, Liem A, Miller EC, Miller JA: Age- and sex-related differences in activation of the carcinogen 7-hydroxymethyl-12-methylbenz [a] anthracene to an electrophilic sulfuric acid ester metabolite in rats. Biochem Pharmacol. 1991 Jan 15;41(2):213-21.

Possible involvement of hydroxysteroid sulfotransferase activity..
Pentachlorophenol, a potent phenol sulfotransferase inhibitor, had little effect in this regard.
2(0,0,0,2) Details