Protein Information

Name complex is
Synonyms 39kD; CI 39kD; Complex I; Complex I 39kD; NADH dehydrogenase (ubiquinone) Fe S protein 2 like; NADH ubiquinone oxidoreductase 39 kDa subunit mitochondrial; NADH ubiquinone oxidoreductase 39 kDa subunit; NDUFA 9…

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
16870562 Zhou J, Kye YS, Kolesnikov AI, Harbison GS: Origins of isotopomeric polymorphism. Isotopes Environ Health Stud. 2006 Sep;42(3):271-7.

If the same complex is synthesized from deuterated pentachlorophenol, it crystallizes in an entirely different monoclinic polymorph.
81(1,1,1,1) Details
15237992 Zhou J, Kye YS, Harbison GS: Isotopomeric polymorphism. J Am Chem Soc. 2004 Jul 14;126(27):8392-3.

If the same complex is synthesized from deuterated pentachlorophenol (4MPPCP-d1), it crystallizes in an entirely different monoclinic polymorph.
81(1,1,1,1) Details
10486141 Maklashina E, Cecchini G: Comparison of catalytic activity and inhibitors of quinone reactions of succinate dehydrogenase (Succinate-ubiquinone oxidoreductase) and fumarate reductase (Menaquinol-fumarate oxidoreductase) from Escherichia coli. Arch Biochem Biophys. 1999 Sep 15;369(2):223-32.

In addition, the isolated E. coli SQR complex demonstrates a mixed-type inhibition with carboxanilides, whereas the QFR complex is resistant to this inhibitor.
A series of 2-alkyl-4,6-dinitrophenols and pentachlorophenol were found to be potent competitive inhibitors of both SQR and QFR.
1(0,0,0,1) Details