| Name | phenol sulfotransferase |
|---|---|
| Synonyms | Aryl sulfotransferase; STP; Aryl sulfotransferase 1; HAST1/HAST2; P PST; P PST 1; PST; Phenol preferring phenol sulfotransferase 1… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10773360 | Boles JW, Klaassen CD: Effects of and pentachlorophenol on the sulfation of Toxicology. 2000 Apr 20;146(1):23-35. Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. |
81(1,1,1,1) | Details |
| 19484729 | Liu Y, Glatt H: Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis. Environ Mol Mutagen. 2010 Jan;51(1):23-30. This phenomenon was moderately, strongly, and completely prohibited in the presence of CYP2E1 inhibitor 1-aminobenzotriazole, SULT1A1 inhibitor pentachlorophenol and both in combination, respectively. |
34(0,1,1,4) | Details |
| 1429499 | Gong DW, Murayama N, Yamazoe Y, Kato R: Hepatic sulfation and its regulation by growth hormone and in rats. J Biochem. 1992 Jul;112(1):112-6. Cytosolic T3 sulfation was inhibited by the addition of known inhibitors of phenol sulfotransferase, pentachlorophenol or 2,6-dichloro- |
32(0,1,1,2) | Details |
| 18616954 | Liu Y, Glatt H: Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes. Mutat Res. 2008 Aug 25;643(1-2):64-9. Epub 2008 Jun 21. Mutagenicity of NDELA in V79-hCYP2E1-hSULT1A1 cells was abolished by the CYP2E1 inhibitor 1-aminobenzotriazole, but unaffected by the SULT1A1 inhibitor pentachlorophenol. |
32(0,1,1,2) | Details |
| 10378445 | Boles JW, Klaassen CD: Effects of and pentachlorophenol on the sulfation of alpha-naphthol. Toxicol Lett. 1999 May 20;106(1):1-8. The phenol-sulfotransferase inhibitor pentachlorophenol (PCP) is often used to distinguish the biological effects of a chemical from its conjugate. |
31(0,1,1,1) | Details |
| 1824923 | Surh YJ, Liem A, Miller EC, Miller JA: Age- and sex-related differences in activation of the carcinogen 7-hydroxymethyl-12-methylbenz [a] anthracene to an electrophilic sulfuric acid ester metabolite in rats. Biochem Pharmacol. 1991 Jan 15;41(2):213-21. Pentachlorophenol, a potent phenol sulfotransferase inhibitor, had little effect in this regard. |
31(0,1,1,1) | Details |
| 10799342 | Duanmu Z, Dunbar J, Falany CN, Runge-Morris M: Induction of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by triamcinolone acetonide: impact on minoxidil-mediated hypotension. Toxicol Appl Pharmacol. 2000 May 1;164(3):312-20. Pentachlorophenol (PCP, 40 micromol/kg i.p.), an inhibitor of SULT1 enzyme activity, effectively ablated the hypotensive effects of minoxidil. |
5(0,0,0,5) | Details |
| 16161050 | Meinl W, Pabel U, Osterloh-Quiroz M, Hengstler JG, Glatt H: Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. Int J Cancer. 2006 Mar 1;118(5):1090-7. SULT1A1 led to the strongest increase in the mutagenicity of aristolochic acids. Furthermore, pentachlorophenol, an inhibitor of SULT1A1, strongly reduced the mutagenic effect of aristolochic acids in V79-hCYP2E1-hSULT1A1 cells. |
4(0,0,0,4) | Details |
| 12167648 | Tulik GR, Chodavarapu S, Edgar R, Giannunzio L, Langland A, Schultz B, Beckmann JD: Inhibition of bovine phenol sulfotransferase (bSULT1A1) by thioesters. J Biol Chem. 2002 Oct 18;277(42):39296-303. Epub 2002 Aug 6. Second, prevented the quenching of bSULT1A1 fluorescence observed with pentachlorophenol. |
2(0,0,0,2) | Details |
| 9566736 | Beckmann JD, Henry T, Ulphani J, Lee P: Cooperative ligand binding by bovine phenol sulfotransferase. . Chem Biol Interact. 1998 Feb 20;109(1-3):93-105. Inhibition of a purified recombinant homodimeric bovine PST by 2,6-dichloro- (DCNP) and pentachlorophenol (PCP) displayed very sharp titration curves that required modeling with Hill equations with slope factors of 2 and 3, respectively. |
2(0,0,0,2) | Details |
| 2791985 | Rooda SJ, Otten MH, van Loon MA, Kaptein E, Visser TJ: Metabolism of in rat hepatocytes. . Endocrinology. 1989 Oct;125(4):2187-97. Type I iodothyronine deiodinase activity was inhibited with propylthiouracil (PTU), and phenol sulfotransferase activity by SO4 (2-) depletion or with competitive substrates or inhibitors. |
2(0,0,0,2) | Details |
| 10670822 | Bostrom M, Becedas L, DePierre JW: Conjugation of 1-naphthol in primary cell cultures of rat ovarian cells. Chem Biol Interact. 2000 Jan 15;124(2):103-18. Two phase II enzymes catalyzing conjugation, i.e. phenol sulfotransferase (P-SULT) and UDP-glucuronosyltransferase (P-UGT), were measured using 1-naphthol as substrate. Pentachlorophenol (PCP), a commonly used inhibitor of P-SULT, inhibited 1-naphthol conjugation 50% in cell cultures, as well as in microsomal preparations. alpha-Naphthoflavone (ANF) and ellipticine (ELP), both cytochrome P450 (CYP) inhibitors, affected the conjugation of 1-naphthol in different ways; ANF did not affect P-UGT activity in microsomal preparations, but inhibited 1-naphthol conjugation in cell cultures by as much as 90%. |
1(0,0,0,1) | Details |
| 12758156 | Beckmann JD, Burkett RJ, Sharpe M, Giannunzio L, Johnston D, Abbey S, Wyman A, Sung L: Spectrofluorimetric analysis of 7-hydroxycoumarin binding to bovine phenol sulfotransferase. Biochim Biophys Acta. 2003 May 30;1648(1-2):134-9. The bSULT1A1:PAP:7-HC complex could be disrupted with pentachlorophenol (PCP), titrations with which indicated 0.5 equivalents per enzyme subunit. |
3(0,0,0,3) | Details |
| 18656962 | Gulcan HO, Liu Y, Duffel MW: Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol. 2008 Aug;21(8):1503-8. Epub 2008 Jul 26. Even though some of the -substituted phenols, and particularly PCP, are well-known inhibitors of phenol sulfotransferases (SULTs), these compounds have been shown to undergo sulfation in humans. |
1(0,0,0,1) | Details |
| 9602860 | Kreis P, Degen GH, Andrae U: Sulfotransferase-mediated genotoxicity of propane 2-nitronate in cultured ovine seminal vesicle cells. Mutat Res. 1998 Feb 23;413(1):69-81. In contrast, the sulfotransferase inhibitor pentachlorophenol strongly reduced genotoxicity. OSV cells lack cytochrome P450-dependent monooxygenase activity, but express prostaglandin-H-synthase (PHS) and, as we found out, phenol sulfotransferase. |
1(0,0,0,1) | Details |
| 9705892 | Boles JW, Klaassen CD: Effects of and pentachlorophenol on the sulfation of Toxicol Appl Pharmacol. 1998 Jul;151(1):105-9. |
0(0,0,0,0) | Details |