Protein Information

Name Microsomal monooxygenase
Synonyms ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1…

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
16714371 Diani-Moore S, Papachristou F, Labitzke E, Rifkind AB: Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab Dispos. 2006 Aug;34(8):1376-85. Epub 2006 May 19.

We report here that imidazole derivative drugs: the anthelminthics, albendazole and thiabendazole; the proton pump inhibitor, omeprazole; the thromboxane synthase inhibitor, benzylimidazole; and the aromatase (CYP19) inhibitor vorozole (R76713, racemate; and R83842, (+) enantiomer) increased hepatic microsomal EET formation in a chick embryo model.		 31(0,1,1,1) Details
1473796 Tada Y, Fujitani T, Yoneyama M: Acute renal toxicity of thiabendazole (TBZ) in ICR mice. Food Chem Toxicol. 1992 Dec;30(12):1021-30.

TBZ-induced renal injury was reduced by pretreatment with inducers of the microsomal monooxygenase system (sodium phenobarbital, beta-naphthoflavone and 3-methylcholanthrene) and were enhanced by pretreatment with inhibitors of that system (2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride and piperonyl butoxide).		 2(0,0,0,2) Details