| Name | alpha tubulin |
|---|---|
| Synonyms | Alpha tubulin ubiquitous; Tubulin K alpha 1; Tubulin alpha ubiquitous chain; K alpha 1; K ALPHA 1 protein; alpha tubulin; K alpha 1s; K ALPHA 1 proteins… |
| Name | thiabendazole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15280226 | Tange Y, Fujita A, Toda T, Niwa O: Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe. Genetics. 2004 Jul;167(3):1095-107. The cold sensitivity of gamma-tubulin mutants was almost completely suppressed by an alpha-tubulin mutation and partially suppressed by a low concentration of thiabendazole, a microtubule assembly inhibitor. |
81(1,1,1,1) | Details |
| 11077003 | Pisano C, Battistoni A, Antoccia A, Degrassi F, Tanzarella C: Changes in microtubule organization after exposure to a benzimidazole derivative in Chinese hamster cells. Mutagenesis. 2000 Nov;15(6):507-15. Furthermore, thiabendazole strongly induced multipolar and asymmetric alpha-tubulin-positive metaphase spindles, characterized, however, by the absence of fragmentation of centrosome material as evaluated by anti-gamma-tubulin antibody staining. |
6(0,0,1,1) | Details |
| 6327053 | Toda T, Adachi Y, Hiraoka Y, Yanagida M: Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe. Cell. 1984 May;37(1):233-42. Mutations in a cell-cycle gene NDA2 of Schizosaccharomyces pombe have pleiotropic effects on nuclear division, nuclear location, and thiabendazole sensitivity ( Toda et al., 1983). |
3(0,0,0,3) | Details |
| 3785193 | Adachi Y, Toda T, Niwa O, Yanagida M: Differential expressions of essential and nonessential alpha-tubulin genes in Schizosaccharomyces pombe. Mol Cell Biol. 1986 Jun;6(6):2168-78. The alpha 2-disrupted cells had an increased sensitivity to an antimicrotubule drug thiabendazole, and the alpha 1 (cold-sensitive [cs]) alpha 2 (disrupted) cells became not only cs but also temperature sensitive. |
2(0,0,0,2) | Details |
| 7910461 | Lubega GW, Klein RD, Geary TG, Prichard RK: Haemonchus contortus: the role of two beta-tubulin gene subfamilies in the resistance to benzimidazole anthelmintics. Biochem Pharmacol. 1994 Apr 29;47(9):1705-15. The Rt strain was isolated from the field on the basis of thiabendazole resistance. The Rc strain was derived from the S strain by treatment with cambendazole. cDNAs, derived from the S strain, encoding two isoforms of beta-tubulin (beta 12-16 and beta 8-9), alpha-tubulin and phosphofructokinase (Pfk) were used as probes for Southern hybridization analysis of genomic DNA digested by restriction enzymes. |
1(0,0,0,1) | Details |
| 9471999 | Ding DQ, Chikashige Y, Haraguchi T, Hiraoka Y: Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J Cell Sci. 1998 Mar;111 ( Pt 6):701-12. To obtain a dynamic view of this oscillatory nuclear movement in meiotic prophase, we visualized microtubules and chromosomes in living cells using jellyfish green fluorescent protein fused with alpha-tubulin and a DNA-specific fluorescent dye, Hoechst 33342, respectively. Reversible inhibition of nuclear movement by an inhibitor of microtubule polymerization, thiabendazole, confirmed the involvement of astral microtubules in oscillatory nuclear movement. |
1(0,0,0,1) | Details |
| 1981249 | Roos MH, Boersema JH, Borgsteede FH, Cornelissen J, Taylor M, Ruitenberg EJ: Molecular analysis of selection for benzimidazole resistance in the sheep parasite Haemonchus contortus. Mol Biochem Parasitol. 1990 Nov;43(1):77-88. Three BZ-susceptible and three resistant populations from different geographical locations were characterized with respect to the egg-hatch assay with thiabendazole (TBZ), mebendazole (MBZ) binding tests and restriction fragment length polymorphism (RFLP) after Southern blotting. The three resistant populations showed as many fragments with the alpha-tubulin probe as the susceptible populations, but when probed with beta-tubulin only 1 or 2 fragments were visible, but always less than in the susceptible populations. |
1(0,0,0,1) | Details |