| Name | methionine aminopeptidase |
|---|---|
| Synonyms | MAP; MAP 1; METAP1; MetAP 1; Methionine aminopeptidase; Methionine aminopeptidase 1; Methionyl Aminopeptidase 1; Peptidase M… |
| Name | thiabendazole |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16420038 | Schiffmann R, Neugebauer A, Klein CD: Metal-mediated inhibition of Escherichia coli methionine aminopeptidase: structure-activity relationships and development of a novel scoring function for metal-ligand interactions. J Med Chem. 2006 Jan 26;49(2):511-22. We report the discovery of thiabendazole as a potent inhibitor (K (i) = 0.4 microM) of Escherichia coli methionine aminopeptidase (ecMetAP) and the synthesis and pharmacological evaluation of thiabendazole congeners with activity in the upper nanomolar range. |
82(1,1,1,2) | Details |
| 15880695 | Schiffmann R, Heine A, Klebe G, Klein CD: Metal ions as cofactors for the binding of inhibitors to methionine aminopeptidase: a critical view of the relevance of in vitro metalloenzyme assays. Angew Chem Int Ed Engl. 2005 Jun 6;44(23):3620-3. |
1(0,0,0,1) | Details |