Protein Information

Name proton pump
Synonyms ATP12A; Cation transporting ATPase; Proton pump; ATP12A protein; ATP1AL1; Non gastric H(+)/K(+) ATPase subunit alpha; Non gastric H+/K+ ATPase alpha subunit; Potassium transporting ATPase alpha chain 2…

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
16714371 Diani-Moore S, Papachristou F, Labitzke E, Rifkind AB: Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole. Drug Metab Dispos. 2006 Aug;34(8):1376-85. Epub 2006 May 19.

We report here that imidazole derivative drugs: the anthelminthics, albendazole and thiabendazole; the proton pump inhibitor, omeprazole; the thromboxane synthase inhibitor, benzylimidazole; and the aromatase (CYP19) inhibitor vorozole (R76713, racemate; and R83842, (+) enantiomer) increased hepatic microsomal EET formation in a chick embryo model.
31(0,1,1,1) Details
14672851 Velik J, Baliharova V, Fink-Gremmels J, Bull S, Lamka J, Skalova L: Benzimidazole drugs and modulation of biotransformation enzymes. Res Vet Sci. 2004 Apr;76(2):95-108.

Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of biotransformation enzymes, research has been carried out mainly due to the initiative of human pharmacologists.
Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of biotransformation enzymes, research has been carried out mainly due to the initiative of human pharmacologists.
1(0,0,0,1) Details