Protein Information

Name gamma tubulin complex (protein family or complex)
Synonyms Gamma tubulin; Gamma tubulin complex; Gamma tubulins

Compound Information

Name thiabendazole
CAS

Reference List

PubMed Abstract RScore(About this table)
15280226 Tange Y, Fujita A, Toda T, Niwa O: Functional dissection of the gamma-tubulin complex by suppressor analysis of gtb1 and alp4 mutations in Schizosaccharomyces pombe. Genetics. 2004 Jul;167(3):1095-107.

The cold sensitivity of gamma-tubulin mutants was almost completely suppressed by an alpha-tubulin mutation and partially suppressed by a low concentration of thiabendazole, a microtubule assembly inhibitor.
37(0,1,1,7) Details
8089179 Horio T, Oakley BR: Human gamma-tubulin functions in fission yeast. J Cell Biol. 1994 Sep;126(6):1465-73.

Finally, we have found that expression of human gamma-tubulin or overexpression of S. pombe gamma-tubulin causes no significant alteration of resistance to the antimicrotubule agents benomyl, thiabendazole and nocodazole.
8(0,0,0,8) Details
11077003 Pisano C, Battistoni A, Antoccia A, Degrassi F, Tanzarella C: Changes in microtubule organization after exposure to a benzimidazole derivative in Chinese hamster cells. Mutagenesis. 2000 Nov;15(6):507-15.

Furthermore, thiabendazole strongly induced multipolar and asymmetric alpha-tubulin-positive metaphase spindles, characterized, however, by the absence of fragmentation of centrosome material as evaluated by anti-gamma-tubulin antibody staining.
6(0,0,1,1) Details
11080156 Vardy L, Toda T: The fission yeast gamma-tubulin complex is required in G (1) phase and is a component of the spindle assembly checkpoint. EMBO J. 2000 Nov 15;19(22):6098-111.

Alp4 function is required in G (1) phase and ts mutants become lethal before S-phase. alp4 and alp6 mutants are hypersensitive to the microtubule- destabilizing drug thiabendazole (TBZ) and show a lethal 'cut' phenotype in its presence.
4(0,0,0,4) Details