Protein Information

Name NKCC1
Synonyms BSC; BSC 2; BSC2; Basolateral Na K Cl symporter; Bumetanide sensitive sodium potassium chloride cotransporter 1; Bumetanide sensitive sodium (potassium) chloride cotransporter 1; NKCC 1; NKCC1…

Compound Information

Name diphenylamine
CAS

Reference List

PubMed Abstract RScore(About this table)
16859673 Valero MS, Garay RP, Gros P, Alda JO: Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and Na-K-Cl cotransporter NKCC1 isoform mediate the vasorelaxant action of genistein in isolated rat aorta. Eur J Pharmacol. 2006 Aug 21;544(1-3):126-31. Epub 2006 Jun 28.

Isolated, endothelium-denuded rat aorta was contracted with phenylephrine 1 microM, and the vasorelaxant responses to genistein were investigated under conditions where CFTR was inhibited by DPC (diphenylamine-2-carboxylic acid) or glibenclamide (n=6 for compound).
4(0,0,0,4) Details
11117534 Selvaraj NG, Omi E, Gibori G, Rao MC: Janus kinase 2 (JAK2) regulates prolactin-mediated chloride transport in mouse mammary epithelial cells through tyrosine phosphorylation of Na+-K+-2Cl- cotransporter. Mol Endocrinol. 2000 Dec;14(12):2054-65.

This was inhibited by the NKCC1 blocker, furosemide, and by the Cl- channel inhibitor, diphenylamine 2-carboxylate.
35(0,1,1,5) Details