Protein Information

Name prothrombin
Synonyms Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin…

Compound Information

Name allyl alcohol
CAS 2-propen-1-ol

Reference List

PubMed Abstract RScore(About this table)
3977950 Poulsen HE, Lerche A, Pedersen NT: Potentiated hepatotoxicity from concurrent administration of acetaminophen and allyl alcohol to rats. Biochem Pharmacol. 1985 Mar 15;34(6):727-31.

Hepatic function, measured as galactose elimination capacity and prothrombin index, was reduced to about 0.40 times control value.
2(0,0,0,2) Details
6711319 Poulsen HE, Korsholm B: Quantitative liver functions after administration of allyl alcohol to rats. Acta Pharmacol Toxicol. 1984 Feb;54(2):120-3.

Prothrombin index was reduced to a minimum after 12 hours and reestablished after 24 hours.
1(0,0,0,1) Details
12377996 Kinser S, Copple BL, Roth RA, Ganey PE: Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors. Toxicol Sci. 2002 Oct;69(2):470-81.

To assess the role of thrombin in this injury, isolated livers from rats pretreated with LPS were perfused with thrombin or vehicle and allyl alcohol.
6(0,0,1,1) Details