| Name | sorbitol dehydrogenase |
|---|---|
| Synonyms | L iditol 2 dehydrogenase; SORD; SORD 1; SORD 2; SORD1; SORD2; Sorbitol dehydrogenase; Sorbitol dehydrogenase 1… |
| Name | allyl alcohol |
|---|---|
| CAS | 2-propen-1-ol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3668850 | Rikans LE, Moore DR: Effect of age and sex on allyl alcohol hepatotoxicity in rats: role of liver and aldehyde dehydrogenase activities. J Pharmacol Exp Ther. 1987 Oct;243(1):20-6. There was a good correlation (r = 0.99, P less than .001) between liver ADH activity and allyl alcohol-induced hepatotoxicity, measured as the release of sorbitol dehydrogenase into the bloodstream. |
6(0,0,1,1) | Details |
| 2933316 | Belinsky SA, Bradford BU, Forman DT, Glassman EB, Felder MR, Thurman RG: Hepatotoxicity due to allyl alcohol in deermice depends on alcohol dehydrogenase. Hepatology. 1985 Nov-Dec;5(6):1179-82. In contrast, dose-dependent necrosis of periportal regions of the liver and increases in plasma levels of lactate dehydrogenase, sorbitol dehydrogenase and SGOT were observed in plasma from alcohol dehydrogenase-positive deermice (AdhF) 24 hr following administration of allyl alcohol (21 to 84 mg per kg). |
6(0,0,1,1) | Details |
| 8711744 | Dalu A, Mehendale HM: Efficient tissue repair underlies the resiliency of postnatally developing rats to chlordecone + CCl4 hepatotoxicity. Toxicology. 1996 Jul 17;111(1-3):29-42. Recent studies have demonstrated that neonate and postnatally developing rats are resilient to a wide variety of structurally and mechanistically dissimilar hepatotoxicants such as galactosamine, allyl alcohol, and CCl4. In a study where postnatally developing (20- and 45-day), and adult (60-day) male Sprague Dawley rats were used, administration of CCl4 (100 microliters/kg, i.p.) alone resulted in transient liver injury regardless of age as indicated by plasma transaminase (ALT), sorbitol dehydrogenase (SDH) levels and histopathological lesions. |
1(0,0,0,1) | Details |
| 10999434 | Yang M, Chen K, Shih JC: Yang-Gan-Wan protects mice against experimental liver damage. Am J Chin Med. 2000;28(2):155-62. The hepatoprotective effect of Yang-Gan-Wan (YGW, Pro-Liver pill), a Chinese herbal remedy, was investigated in mice that were treated with allyl alcohol (AlOH), (AA) or carbon tetrachloride (CCl4). YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the necrosis induced by AlOH. |
1(0,0,0,1) | Details |
| 7934088 | Liu J, Liu Y, Klaassen CD: The effect of Chinese hepatoprotective medicines on experimental liver injury in mice. J Ethnopharmacol. 1994 May;42(3):183-91. Acute liver injury was produced in male CF-1 mice by CCl4, cadmium and allyl alcohol. Liver damage was assessed by quantifying serum activities of sorbitol dehydrogenase and alanine aminotransferase, as well as by histopathological examination. |
1(0,0,0,1) | Details |
| 2418542 | Trela BA, Carlson GP, Chadwick RW, Copeland MF: Comparison of in vivo and in vitro methods for assessing effects of allyl alcohol on the liver. Toxicol Lett. 1985 Dec;29(2-3):77-84. Plasma sorbitol dehydrogenase was minimally elevated. |
1(0,0,0,1) | Details |
| 2886311 | Rikans LE: The oxidation of acrolein by rat liver aldehyde dehydrogenases. Drug Metab Dispos. 1987 May-Jun;15(3):356-62. Relation to allyl alcohol hepatotoxicity.. Hepatotoxicity was assessed on the basis of elevated serum alanine aminotransferase and sorbitol dehydrogenase activities and the loss of microsomal cytochrome P-450. |
1(0,0,0,1) | Details |
| 3729968 | Wendel A, Tiegs G: A novel biologically active seleno-organic compound--VI. Biochem Pharmacol. 1986 Jul 1;35(13):2115-8. Similarly negative results were obtained against bromobenzene-induced hepatotoxicity (520 mg/kg bromobenzene i.p.), carbon tetrachloride intoxication (3.2 g/kg), or allyl alcohol-induced liver damage (60 mg/kg). After 9 hr, serum sorbitol dehydrogenase activity had risen from 60 to 7320 U/l, SGOT from 90 to 5580, and SGPT from 70 to 10,440. |
1(0,0,0,1) | Details |
| 7597924 | Liu J, Liu Y, Klaassen CD: Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice. Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):97-102. Liver damage was assessed by quantifying serum activities of alanine aminotransferase and iditol (sorbitol) dehydrogenase, as well as by histopathological examination. However, OA had no effect on the toxicity of dimethylnitrosamine, alpha-amanitin, chloroform, and allyl alcohol. |
1(0,0,0,1) | Details |
| 3999032 | Haddad P, Gascon-Barre M, Dumont A: Comparative hepatic response to bromobenzene and allyl alcohol in the -replete and -depleted rat. J Pharmacol Exp Ther. 1985 May;233(2):499-506. The severity of the hepatotoxicity was evaluated by the serum concentrations of aspartate aminotransferase, alanine aminotransferase and sorbitol dehydrogenase, the histomorphological appearance of the lesions, and the amount of cytochrome P-450 destroyed. |
1(0,0,0,1) | Details |
| 1949007 | Maziasz TJ, Liu J, Madhu C, Klaassen CD: The differential effects of hepatotoxicants on the sulfation pathway in rats. Toxicol Appl Pharmacol. 1991 Sep 15;110(3):365-73. Specifically, the concentration of cosubstrate, 3'- 5'- and the hepatic capacity for synthesis were measured in livers of rats treated with carbon tetrachloride (CCl4), 1,1-dichloroethylene (DCE), alpha-naphthylisothiocyanate (ANIT), (ATX), allyl alcohol (AA), bromobenzene (BB), cadmium (Cd), or thioacetamide (TA). Liver damage was assessed by measuring serum sorbitol dehydrogenase (SDH) and alanine aminotransferase (ALT) activities as well as by histopathological examination. |
1(0,0,0,1) | Details |
| 3787616 | Zieve L, Anderson WR, Lyftogt C, Draves K: Hepatic regenerative enzyme activity after pericentral and periportal lobular toxic injury. Toxicol Appl Pharmacol. 1986 Nov;86(2):147-58. Pericentral and periportal liver injuries involving less than 50% of the parenchyma were produced with and allyl alcohol, respectively. Doses were selected to produce comparable peak serum malate dehydrogenase, sorbitol dehydrogenase, and SGPT activities. |
1(0,0,0,1) | Details |