| PubMed |
Abstract |
RScore(About this table) |
| 15727878 |
Bojarski AJ, Paluchowska MH, Duszynska B, Klodzinska A, Tatarczynska E, Chojnacka-Wojcik E: 1-Aryl-4-(4-succinimidobutyl) piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics. Bioorg Med Chem. 2005 Mar 15;13(6):2293-303.
|
6(0,0,0,6) |
Details |
| 19665823 |
Herold F, Izbicki L, Chodkowski A, Dawidowski M, Krol M, Kleps J, Turlo J, Wolska I, Nowak G, Stachowicz K, Dybala M, Siwek A, Nowak M, Pieniazek E, Jaronczyk M, Sylte I, Mazurek AP: Novel 4-aryl-pyrido [1,2-c] pyrimidines with dual SSRI and 5-HT1A activity: part 2. Eur J Med Chem. 2009 Nov;44(11):4702-15. Epub 2009 Jul 16.
|
5(0,0,0,5) |
Details |
| 16600439 |
Obniska J, Kolaczkowski M, Bojarski AJ, Duszynska B: Synthesis, anticonvulsant activity and 5-HT1A, 5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-alkyl] derivatives of 2-azaspiro [4.4] nonane and [4.5] decane-1,3-dione. Eur J Med Chem. 2006 Jul;41(7):874-81. Epub 2006 Apr 4.
|
5(0,0,0,5) |
Details |
| 16266808 |
Bojarski AJ, Paluchowska MH, Duszynska B, Bugno R, Klodzinska A, Tatarczynska E, Chojnacka-Wojcik E: Structure-intrinsic activity relationship studies in the group of 1-imido/amido substituted 4-(4-arylpiperazin-1-yl) cyclohexane derivatives; new, potent 5-HT1A receptor agents with anxiolytic- like activity. Bioorg Med Chem. 2006 Mar 1;14(5):1391-402. Epub 2005 Nov 2.
|
5(0,0,0,5) |
Details |
| 17194034 |
Sharma BK, Singh P, Sharma S: Quantitative structure-activity relationship study of new potent and selective antagonists at the 5-HT (1A) and adrenergic alpha (1d) receptors: Derivatives of spiroethyl phenyl (substituted) piperazine. J Enzyme Inhib Med Chem. 2006 Oct;21(5):601-7.
|
3(0,0,0,3) |
Details |
| 18995929 |
Herold F, Chodkowski A, Izbicki L, Krol M, Kleps J, Turlo J, Nowak G, Stachowicz K, Dybala M, Siwek A: Novel 4-aryl-pyrido [1,2-c] pyrimidines with dual SSRI and 5-HT1A activity, part 1. Eur J Med Chem. 2009 Apr;44(4):1710-7. Epub 2008 Sep 30.
In contrast, the presence of a 5-methoxy-3-(4-piperidyl)-1H-indole residue as well as -Cl or -OCH (3) substituents at the para position markedly reduced the receptor affinity. |
2(0,0,0,2) |
Details |