| 17350742 |
Hong X, Qu J, Wang Y, Sun H, Song L, Wang S, Wang X: Study on the mechanism of trichlorfon-induced inhibition of progesterone synthesis in mouse leydig tumor cells (MLTC-1). Toxicology. 2007 May 5;234(1-2):51-8. Epub 2007 Feb 4.
Moreover, trichlorfon suppressed the expression of the steroidogenic acute regulatory protein (StAR) mRNA and protein, and also profoundly inhibited the activity of P450 side chain cleavage enzyme (P450scc), rather than 3beta-hydorxysteroid dehydrogenase (3beta-HSD). |
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| 17329077 |
Hong X, Qu J, Chen J, Cheng S, Wang Y, Song L, Wang S, Liu J, Wang X: Effects of trichlorfon on progesterone production in cultured human granulosa-lutein cells. Toxicol In Vitro. 2007 Aug;21(5):912-8. Epub 2007 Jan 23.
Furthermore, our results found that 22 (R)-hydroxycholesterol (22R-HC) could remove the inhibitory action of trichlorfon on progesterone biosynthesis, indicating that trichlorfon caused a disruption of cholesterol transport across mitochondrial membranes, which was further confirmed by the observation that trichlorfon dose-dependently inhibited the mRNA level of the steroidogenic acute regulatory protein (StAR). |
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