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Guo Y, Chen X, Jia H, Ji X, Liu B: Synthesis and biological evaluation of one novel technetium-99m-labeled nitroquipazine derivative as an imaging agent for serotonin transporter. Appl Radiat Isot. 2008 Dec;66(12):1804-9. Epub 2008 Jun 19.
For the development of new (99m) Tc-labeled 6-nitroquipazine derivatives as SERT imaging agents, novel [N-[2-((3-(4-(6-nitroquinolin-2-yl) piperazin-1-yl) propyl)(2-mercaptoethyl) amino]-acetyl-2-aminoethanethiolato] [(99m) Tc] technetium (V) oxide ((99m) Tc-MAMA-3-PQ) and its rhenium analog were synthesized and characterized. (99m) Tc-MAMA-3-PQ displayed high initial brain uptake (0.52% ID/organ at 2 min post-injection (pi)) and relatively fast washout in mice (0.09% ID/organ at 60 min pi). |
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