Protein Information

Name survivin
Synonyms API 4; API4; Apoptosis inhibitor 4; Apoptosis inhibitor survivin; BIRC 5; BIRC5; Baculoviral IAP repeat containing protein 5; Baculoviral IAP repeat containing protein 5 isoform 1…

Compound Information

Name sodium arsenite
CAS sodium arsenenite

Reference List

PubMed Abstract RScore(About this table)
16497974 Che XF, Zheng CL, Owatari S, Mutoh M, Gotanda T, Jeung HC, Furukawa T, Ikeda R, Yamamoto M, Haraguchi M, Arima N, Akiyama S: Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines. Blood. 2006 Jun 15;107(12):4880-7. Epub 2006 Feb 23.

Sodium arsenite was shown to down-regulate the expression of survivin at both the protein and RNA levels in a time- and dose-dependent manner, thus inhibiting cell growth, inducing apoptosis, and enhancing the caspase-3 activity in ATL cells.
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