| Name | MAPK (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10964950 | Namgung U, Xia Z: Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. J Neurosci. 2000 Sep 1;20(17):6442-51. Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment. |
2(0,0,0,2) | Details |
| 18836437 | Arimoto K, Fukuda H, Imajoh-Ohmi S, Saito H, Takekawa M: Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways. Nat Cell Biol. 2008 Nov;10(11):1324-32. Epub 2008 Oct 5. |
2(0,0,0,2) | Details |
| 16797887 | Suzuki T, Tsukamoto I: Arsenite induces apoptosis in hepatocytes through an enhancement of the activation of Jun N-terminal kinase and p38 mitogen-activated protein kinase caused by partial hepatectomy. Toxicol Lett. 2006 Sep 10;165(3):257-64. Epub 2006 May 12. To investigate the effects of arsenite on cell proliferation and the signal transduction in hapatocytes in vivo, rats received a single injection of sodium arsenite immediately after partial hepatectomy. |
2(0,0,0,2) | Details |
| 8902523 | Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ: Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radic Biol Med. 1996;21(6):771-81. Exposure of cells to either proliferative or stressful stimuli elicits a complex response involving one or more distinct phosphorylation cascades culminating in the activation of multiple members of the mitogen-activated protein kinase (MAPK) family, including extracellular signal regulated kinase (ERK), stress-activated c-Jun N-terminal kinase (JNK/SAPK), and p38/RK/CSBP protein kinase. In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite. |
1(0,0,0,1) | Details |
| 10779545 | Werz O, Klemm J, Samuelsson B, Radmark O: 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5261-6. Here we describe that activation of p38 mitogen-activated protein kinase in human polymorphonuclear leukocytes and in Mono Mac 6 cells leads to activation of downstream kinases, which can subsequently phosphorylate 5-LO in vitro. Different agents activated the 5-LO kinase activities, including stimuli for cellular leukotriene biosynthesis (A23187, thapsigargin, N-formyl-leucyl- compounds that up-regulate the capacity for leukotriene biosynthesis (phorbol 12- 13- tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor), and well known p38 stimuli as sodium arsenite and |
1(0,0,0,1) | Details |
| 10986282 | Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH, Kong AN: Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem. 2000 Dec 22;275(51):39907-13. Here, we report that the expression of mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1), transforming growth factor-beta-activated kinase (TAK1), and apoptosis signal-regulating kinase (ASK1) in HepG2 cells activated the ARE reporter gene, whereas the expression of their dominant-negative mutants impaired ARE activation by the chemicals sodium arsenite and mercury |
1(0,0,0,1) | Details |
| 17645694 | Lin AM, Fang SF, Chao PL, Yang CH: attenuates arsenite-induced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res. 2007 Sep;43(2):163-71. In the present study, the protective effect of on sodium arsenite (arsenite)-induced apoptosis was investigated. Furthermore, attenuated arsenite-induced increases in heat shock protein 70 and heme oxygenase-1 as well as phosphorylation of p38 mitogen-activated protein kinase and elevations in cyclooxygenase II and inducible synthase expression. |
1(0,0,0,1) | Details |
| 9712902 | Cheong J, Coligan JE, Shuman JD: Activating transcription factor-2 regulates phosphoenolpyruvate carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. J Biol Chem. 1998 Aug 28;273(35):22714-8. We demonstrate that p38beta mitogen-activated protein (MAP) kinase augments ATF-2 transactivation activity on the PEPCK-C promoter, which is consistent with the interpretation that PEPCK-C promoter activity is maintained under stress through a p38 MAP kinase dependent pathway. In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter. |
1(0,0,0,1) | Details |
| 7851416 | Huot J, Lambert H, Lavoie JN, Guimond A, Houle F, Landry J: Characterization of 45-kDa/54-kDa HSP27 kinase, a stress-sensitive kinase which may activate the phosphorylation-dependent protective function of mammalian 27-kDa heat-shock protein HSP27. Eur J Biochem. 1995 Jan 15;227(1-2):416-27. The kinase activity in extracts of cells stimulated by heat shock, H2O2, sodium arsenite, TNF or growth factors was identified by in-gel renaturation and purified approximately 8000-fold by sequential chromatography. In all cases, the induced kinase activity was entirely associated with two polypeptides of 45 kDa and 54 kDa, identified as mitogen-activated-protein kinase-activated protein (MAPKAP) kinase-2 based on its reactivation in vitro by 42/44-kDa MAP kinases, its antigenic properties and its substrate specificity. |
1(0,0,0,1) | Details |
| 18476811 | Zeng Y, Sankala H, Zhang X, Graves PR: Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem J. 2008 Aug 1;413(3):429-36. Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]. Finally, mutation of serine-387 to an residue or treatment of cells with a p38 MAPK inhibitor reduced the localization of Ago2 to processing bodies. |
1(0,0,0,1) | Details |
| 16818494 | Cai B, Chang SH, Becker EB, Bonni A, Xia Z: p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem. 2006 Sep 1;281(35):25215-22. Epub 2006 Jul 3. The stress-activated c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein (MAP) kinase (p38) regulate apoptosis induced by several forms of cellular insults. Here we report evidence that sodium arsenite-induced apoptosis in PC12 cells may be due to direct phosphorylation of Bim (EL) at Ser-65 by p38. |
1(0,0,0,1) | Details |
| 15734884 | Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF Jr: EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H99-H107. Epub 2005 Feb 25. In this study, we sought to explore the signaling pathway triggered by sodium arsenite and its implication for endothelial phenotype. Arsenite-induced activation of JNK and p38 MAPK was distinct, with only JNK as a downstream target of the EGF receptor. |
1(0,0,0,1) | Details |
| 15797874 | Zhang N, Ahsan MH, Zhu L, Sambucetti LC, Purchio AF, West DB: NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation. J Biol Chem. 2005 Jun 3;280(22):21400-8. Epub 2005 Mar 29. MAPK inhibitors had transient and inconsistent effects on LPS-induced luciferase expression. We found that a number of agents that induce oxidative stress, such as sodium arsenite, CCl4, lipopolysaccharide (LPS), or tumor necrosis factor-alpha, are able to induce luciferase expression throughout the entire animal. |
1(0,0,0,1) | Details |
| 19429265 | Das J, Ghosh J, Manna P, Sinha M, Sil PC: protects rat testes against NaAsO (2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicol Lett. 2009 Jun 22;187(3):201-10. Epub 2009 Mar 14. Arsenite has also been shown to induce activation of mitogen-activated protein kinases (MAPKs), Akt as well as NF-kappaB (p65) in testicular tissue. |
1(0,0,0,1) | Details |
| 11862762 | Kozawa O, Tokuda H: [Heat shock protein 27 in osteoblasts] . Nippon Yakurigaku Zasshi. 2002 Feb;119(2):89-94. Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC). In addition, the mitogen-activated protein (MAP) kinase super-family takes part in the HSP27 induction. |
1(0,0,0,1) | Details |
| 8917425 | Kawasaki H, Moriguchi T, Matsuda S, Li HZ, Nakamura S, Shimohama S, Kimura J, Gotoh Y, Nishida E: Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinase cascade. Eur J Biochem. 1996 Oct 15;241(2):315-21. We have previously shown that osmotic stress activates both the mitogen-activated protein kinase (MAPK) cascade and the stress-activated protein kinase (SAPK, also known as JNK) cascade in rat fibroblastic 3Y1 cells and rat PC12 cells. Here, we show that treatment of these cells with sodium arsenite, a chemical compound that mimics the effects of heat shock, or anisomycin, a protein synthesis inhibitor, induces activation of SAPKs potently. |
1(0,0,0,1) | Details |
| 8971075 | Sutherland C, Tebbey PW, Granner DK: Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells. Diabetes. 1997 Jan;46(1):17-22. The reactivating kinase (RK, also known as p38 mitogen activated protein kinase) is induced by insulin, peroxide, or meta-arsenite in hepatoma cells, and these effects are blocked by SB203580, a selective inhibitor of RK. |
1(0,0,0,1) | Details |
| 18191166 | Ahlborn GJ, Nelson GM, Ward WO, Knapp G, Allen JW, Ouyang M, Roop BC, Chen Y, O'Brien T, Kitchin KT, Delker DA: Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxicol Appl Pharmacol. 2008 Mar 15;227(3):400-16. Epub 2007 Nov 28. Only the highest dose (10 ppm) resulted in significantly altered KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including MAPK, regulation of actin cytoskeleton, Wnt, Jak-Stat, Tight junction, Toll-like, phosphatidylinositol and insulin signaling pathways. |
1(0,0,0,1) | Details |
| 11698504 | Werz O, Klemm J, Radmark O, Samuelsson B: p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line. J Leukoc Biol. 2001 Nov;70(5):830-8. Here we demonstrate that several stimuli of cell stress such as osmotic shock NaCl), oxidative stress peroxide, diamide), chemical stress sodium arsenite, and inflammatory cytokines enhanced cellular 5-LO activity in a B cell line (BL41-E95-A), when added simultaneously with ionophore plus These stimuli also activated p38 mitogen-activated protein (MAP) kinase and downstream MAP kinase-activated protein kinases in BL41-E95-A cells, which could phosphorylate 5-LO or heat shock protein 27 in vitro. |
1(0,0,0,1) | Details |
| 9768359 | Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ: Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol. 1998 Sep 24;8(19):1049-57. BACKGROUND: Mitogen-activated protein (MAP) kinases (or extracellular signal regulated kinases; Erks) and stress-activated protein (SAP) kinases mediate cellular responses to a wide variety of signals. |
1(0,0,0,1) | Details |
| 15184373 | Huntington JT, Shields JM, Der CJ, Wyatt CA, Benbow U, Slingluff CL Jr, Brinckerhoff CE: Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. J Biol Chem. 2004 Aug 6;279(32):33168-76. Epub 2004 Jun 7. The Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) pathway is a major regulator of melanoma cell proliferation. |
1(0,0,0,1) | Details |
| 19672740 | Roy A, Manna P, Sil PC: Prophylactic role of on arsenic mediated oxidative renal dysfunction via MAPKs/ NF-kappaB and mitochondria dependent pathways. Free Radic Res. 2009 Oct;43(10):995-1007. Epub 2009 Aug 11. Investigating the responsible signalling cascades, it was found that NaAsO (2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. |
1(0,0,0,1) | Details |
| 9722676 | Masuya Y, Hioki K, Tokunaga R, Taketani S: Involvement of the phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium J Biochem. 1998 Sep;124(3):628-33. These results indicated that signal transduction involving kinase rather than the MAPK family regulates the induction of human HO-1 gene expression by stress inducers. |
1(0,0,0,1) | Details |
| 10704466 | Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA: Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000 Mar 6;191(5):859-70. The mitogen-activated protein (MAP) kinase p38 is a key component of stress response pathways and the target of cytokine-suppressing antiinflammatory drugs (CSAIDs). |
1(0,0,0,1) | Details |
| 12637567 | Kietzmann T, Samoylenko A, Immenschuh S: Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem. 2003 May 16;278(20):17927-36. Epub 2003 Mar 11. Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite. Since mitogen-activated protein kinases (MAPKs) are involved in stress signaling we investigated the role of arsenite and MAPKs for HO-1 gene regulation in primary rat hepatocytes. |
1(0,0,0,1) | Details |
| 18754769 | Hansen TE, Puntervoll P, Seternes OM, Jorgensen JB: Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress. FEBS J. 2008 Oct;275(19):4887-902. Epub 2008 Aug 27. Mitogen activated protein kinase kinase (MKK) 3 and 6 are the main p38 mitogen-activated protein kinase activators in mammals. In cells exposed to sodium arsenite and UV radiation, the different salmon MKK6s were shown to be selectively activated. |
1(0,0,0,1) | Details |
| 10432345 | Flatman PW, Creanor J: Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes. . J Physiol. 1999 Aug 15;519 Pt 1:143-52. The Na+-K+-2Cl- cotransport rate was stimulated by treating erythrocytes with sodium arsenite but not by arsenate (up to 1 mM). |
0(0,0,0,0) | Details |
| 15308334 | Pan F, Zarate J, Choudhury A, Rupprecht R, Bradley TM: Osmotic stress of salmon stimulates upregulation of a cold inducible RNA binding protein (CIRP) similar to that of mammals and amphibians. Biochimie. 2004 Jul;86(7):451-61. Exposure of isolated lamellae to heat stress and sodium arsenite, known inducers of hsps, did not stimulate accumulation of SGRP transcript. |
0(0,0,0,0) | Details |
| 17961518 | DeFuria J, Shea TB: Arsenic inhibits neurofilament transport and induces perikaryal accumulation of phosphorylated neurofilaments: roles of JNK and GSK-3beta. Brain Res. 2007 Nov 21;1181:74-82. Epub 2007 Apr 12. We examined herein the impact of sodium arsenite (the inorganic form of arsenic) on NF dynamics. |
0(0,0,0,0) | Details |
| 11574405 | Elrick LJ, Docherty K: Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes. 2001 Oct;50(10):2244-52. Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm. |
0(0,0,0,0) | Details |
| 15056798 | Trouba KJ, Germolec DR: Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. Toxicol Sci. 2004 Jun;79(2):248-57. Epub 2004 Mar 31. To test this hypothesis, NHEK were exposed to sodium arsenite, and COX-2 expression, (PGE (2)) secretion, mitogen-activated protein kinase (MAPK) phosphorylation, and DNA synthesis were quantified. |
113(1,2,2,3) | Details |
| 11807808 | Kim JY, Choi JA, Kim TH, Yoo YD, Kim JI, Lee YJ, Yoo SY, Cho CK, Lee YS, Lee SJ: Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. J Cell Physiol. 2002 Jan;190(1):29-37. |
82(1,1,1,2) | Details |
| 9288946 | Thomas G, Haavik J, Cohen P: Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells. Eur J Biochem. 1997 Aug 1;247(3):1180-9. Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine chromaffin and rat PC12 cells. |
81(1,1,1,1) | Details |
| 11322385 | Chen YC, Tsai SH, Shen SC, Lin JK, Lee WR: Alternative activation of extracellular signal-regulated protein kinases in and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. Eur J Cell Biol. 2001 Mar;80(3):213-21. MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins. |
81(1,1,1,1) | Details |
| 14962831 | Liu Q, Hofmann PA: Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2204-12. Epub 2004 Feb 12. We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H (2) O (2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H (2) O (2)-stimulated ERK phosphorylation. |
38(0,1,1,8) | Details |
| 10221768 | Burns CJ, Howell SL, Jones PM, Persaud SJ: The p38 mitogen-activated protein kinase cascade is not required for the stimulation of insulin secretion from rat islets of Langerhans. Mol Cell Endocrinol. 1999 Feb 25;148(1-2):29-35. The cellular stress agents sodium arsenite and hyperosmotic significantly stimulated p38 MAPK activity, as did the phosphatase inhibitor pervanadate and the serine/ phosphatase inhibitor okadaic acid. |
33(0,1,1,3) | Details |
| 12482858 | Duyndam MC, Hulscher ST, van der Wall E, Pinedo HM, Boven E: Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. J Biol Chem. 2003 Feb 28;278(9):6885-95. Epub 2002 Dec 13. By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. |
37(0,1,2,2) | Details |
| 11325585 | Chevalier D, Thorin E, Allen BG: Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells. J Pharmacol Toxicol Methods. 2000 Sep-Oct;44(2):429-39. Activation of the mitogen-activated protein kinase (MAP kinase) pathways in cultured porcine aortic vascular smooth muscle cells (VSMCs) was determined following a 5-min stimulation with endothelin-1 (ET-1), phorbol 12- 13- (PMA), H2O2, or sodium arsenite. |
32(0,1,1,2) | Details |
| 17070520 | Ivanov VN, Hei TK: Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res. 2006 Dec 10;312(20):4120-38. Epub 2006 Sep 28. Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. |
31(0,1,1,1) | Details |
| 9688607 | Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT: p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol. 1998 Aug;275(2 Pt 1):C527-34. There is relatively little known about expression and activation of p38 mitogen-activated protein kinases (MAPKs) through G protein-linked, seven-transmembrane-spanning (STM) receptors in mammalian smooth muscle. |
8(0,0,0,8) | Details |
| 12075113 | Muscarella DE, Bloom SE: Differential activation of the c-Jun N-terminal kinase pathway in arsenite-induced apoptosis and sensitization of chemically resistant compared to susceptible B-lymphoma cell lines. Toxicol Sci. 2002 Jul;68(1):82-92. Therefore, we investigated the involvement of key mitogen-activated protein kinase pathways and apoptosis induction by sodium arsenite in a model system of chemically resistant and susceptible B-lymphoma cell lines. |
6(0,0,1,1) | Details |
| 7768904 | Trigon S, Morange M: Different carboxyl-terminal domain kinase activities are induced by heat-shock and arsenite. J Biol Chem. 1995 Jun 2;270(22):13091-8. Characterization of their substrate specificity, separation by Mono Q chromatography, and comparison with the mitogen-activated protein kinases.. We have previously shown that in HeLa cells a protein kinase (HS-CTD kinase) activity is induced rapidly after a heat or sodium arsenite shock. |
3(0,0,0,3) | Details |
| 7923353 | Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 1994 Sep 23;78(6):1027-37. MAPK-activated protein kinase-2 (MAPKAP kinase-2) is activated in vitro by the p42 and p44 isoforms of MAPK (p42/p44MAPK). In several cell lines, however, MAPKAP kinase-2 is activated by sodium arsenite, heat shock, or osmotic stress and not by agonists that activate p42/p44MAPK. |
3(0,0,0,3) | Details |
| 11807011 | Werz O, Burkert E, Samuelsson B, Radmark O, Steinhilber D: Activation of 5-lipoxygenase by cell stress is independent in human polymorphonuclear leukocytes. Blood. 2002 Feb 1;99(3):1044-52. This study showed that various forms of cell stress, such as chemical stress (sodium arsenite), osmotic stress, or heat shock lead to substantial formation of 5-LO products in freshly isolated human polymorphonuclear leukocytes (PMNLs), when exogenous (10 microM) was present. In parallel, cell stress led to activation of p38 MAPK (mitogen-activated protein kinase) and mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) kinases, which can phosphorylate 5-LO in vitro. |
3(0,0,0,3) | Details |
| 12639917 | Vandeput F, Perpete S, Coulonval K, Lamy F, Dumont JE: Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic 5'-monophosphate and growth factors. Endocrinology. 2003 Apr;144(4):1341-9. |
3(0,0,0,3) | Details |
| 10944112 | Goh KC, deVeer MJ, Williams BR: The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 2000 Aug 15;19(16):4292-7. |
3(0,0,0,3) | Details |
| 12842450 | Carter Y, Liu G, Stephens WB, Carter G, Yang J, Mendez C: Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance. J Surg Res. 2003 May 1;111(1):70-7. This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH. |
3(0,0,0,3) | Details |
| 19616567 | Ghosh J, Das J, Manna P, Sil PC: prevents arsenic-induced cardiac oxidative stress and apoptotic damage: role of NF-kappa B, p38 and JNK MAPK pathway. Toxicol Appl Pharmacol. 2009 Oct 1;240(1):73-87. Epub 2009 Jul 17. treatment suppressed these apoptotic actions, suggesting that its protective role in arsenic-induced cardiomyocyte apoptosis is mediated by attenuation of p38 and JNK MAPK signaling pathways. |
2(0,0,0,2) | Details |
| 17373649 | Li JP, Yang JL: Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. J Cell Physiol. 2007 Aug;212(2):481-8. |
2(0,0,0,2) | Details |
| 9535875 | Elbirt KK, Whitmarsh AJ, Davis RJ, Bonkovsky HL: Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. J Biol Chem. 1998 Apr 10;273(15):8922-31. Role of mitogen-activated protein kinases.. |
2(0,0,0,2) | Details |
| 16256366 | Zhao Q, Chen P, Manson ME, Liu Y: Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells. Protein Expr Purif. 2006 Apr;46(2):468-74. Epub 2005 Oct 10. The protein kinases were activated in vivo through treating the transfected cells with sodium arsenite and affinity-purified using -Sepharose beads. |
2(0,0,0,2) | Details |
| 8665897 | Meier R, Rouse J, Cuenda A, Nebreda AR, Cohen P: Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells. Eur J Biochem. 1996 Mar 15;236(3):796-805. In PC12 cells, the same two upstream activators, SAP kinase kinase-1 (SAPKK-1) and SAPKK-2 were activated after exposure to osmotic shock, ultraviolet irradiation or the protein synthesis inhibitor anisomycin, and more weakly in response to sodium arsenite. |
2(0,0,0,2) | Details |