| Name | c fos |
|---|---|
| Synonyms | Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 3412774 | Gubits RM, Fairhurst JL: c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite. Oncogene. 1988 Aug;3(2):163-8. A comparison of relative rates of protein synthesis and c-fos mRNA levels during either heat shock or sodium arsenite treatment suggests that the transient suppression of protein synthesis accompanying these treatments may be one factor responsible for the observed c-fos mRNA induction. |
97(1,1,3,7) | Details |
| 2111988 | Colotta F, Polentarutti N, Staffico M, Fincato G, Mantovani A: Heat shock induces the transcriptional activation of c-fos protooncogene. Biochem Biophys Res Commun. 1990 May 16;168(3):1013-9. Sodium arsenite induced both hsp 70 and c-fos transcripts. |
12(0,0,1,7) | Details |
| 10381381 | Masuya Y, Kameshita I, Fujisawa H, Kohno H, Hioki K, Tokunaga R, Taketani S: MAP kinase-independent induction of proto-oncogene c-fos mRNA by hemin in human cells. Biochem Biophys Res Commun. 1999 Jun 24;260(1):289-95. |
7(0,0,0,7) | Details |
| 12076508 | Hu Y, Jin X, Snow ET: Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. Toxicol Lett. 2002 Jul 7;133(1):33-45. Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As (III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. Short-term treatment with 0.1-5 microM As (III) up-regulates expression of c-Fos and c-Jun and the redox regulators, thioredoxin (Trx) and Redox factor-1 (Ref-1) and activates both AP-1 and NF-kappa B binding. |
2(0,0,0,2) | Details |
| 12210719 | Li M, Cai JF, Chiu JF: Arsenic induces oxidative stress and activates stress gene expressions in cultured lung epithelial cells. J Cell Biochem. 2002;87(1):29-38. Significant elevations in c-fos and c-jun mRNA levels were observed within 30 min after exposure to arsenic and by enhancement of AP-1 DNA binding activity and transactivation activity. |
1(0,0,0,1) | Details |
| 8482719 | Van Wijk R, Welters M, Souren JE, Ovelgonne H, Wiegant FA: Serum-stimulated cell cycle progression and stress protein synthesis in C3H10T1/2 fibroblasts treated with sodium arsenite. J Cell Physiol. 1993 May;155(2):265-72. It is shown that the concentrations of arsenite that enhance the mitogenic effect of serum also increase the mRNA levels of c-fos, HSP68, and HSP84 and induce the specific synthesis of Heat Shock Proteins (HSPs). |
1(0,0,0,1) | Details |
| 10910055 | Simeonova PP, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N, Kayama F, Harki D, Ding M, Vallyathan V, Luster MI: Arsenic mediates cell proliferation and gene expression in the bladder epithelium: association with activating protein-1 transactivation. Cancer Res. 2000 Jul 1;60(13):3445-53. In the current studies, we demonstrate that mice exposed to 0.01% sodium arsenite in drinking water develop hyperplasia of the bladder urothelium within 4 weeks of exposure. Gene expression studies using RNase protection assays, reverse transcription-PCR, and cDNA microarrays indicated that arsenite alters the expression of a number of genes associated with cell growth, such as c-fos, c-jun, and EGR-1, as well as cell arrest, such as GADD153 and GADD45. |
1(0,0,0,1) | Details |
| 18037969 | Wen G, Calaf GM, Partridge MA, Echiburu-Chau C, Zhao Y, Huang S, Chai Y, Li B, Hu B, Hei TK: Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med. 2008 Jan-Feb;14(1-2):2-10. Human small airway epithelial cells (SAECs) previously immortalized with human telomerase reverse transcriptase (h-TERT) were continuously treated with sodium arsenite at a dose of 0.5 microg/mL in culture for up to 6 months. In addition, arsenic-treated cells showed an increase in c-H-ras, c-myc, and c-fos protein expression relative to controls. |
1(0,0,0,1) | Details |