| Name | IL 1beta |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10464058 | Moon R, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Ryan M, Wong HR, Hasselgren PO: Stress response decreases the interleukin-1beta-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci. 1999 Sep;97(3):331-7. The IL-1beta-induced expression of C3 mRNA and C3 production were down-regulated by hyperthermia and sodium arsenite in a dose-dependent fashion. |
116(1,2,2,6) | Details |
| 11835394 | Hershko DD, Robb BW, Hungness ES, Luo G, Hasselgren PO: Arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1 beta-stimulated Caco-2 cells independent of the heat shock response. J Cell Biochem. 2002;84(4):687-98. Sodium arsenite blocked all of these responses to IL-1beta without inducing changes in heat shock factor activity or heat shock protein levels. |
90(1,1,2,5) | Details |
| 12241537 | Hershko DD, Robb BW, Hungness ES, Luo G, Guo X, Hasselgren PO: Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity. Clin Sci. 2002 Oct;103(4):381-90. These effects of IL-1beta were inhibited by treatment of the cells with sodium arsenite in a dose- and time-dependent fashion. |
88(1,1,2,3) | Details |
| 14523996 | Hershko DD, Robb BW, Luo GJ, Hungness ES, Hasselgren PO: Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha. J Cell Biochem. 2003 Oct 15;90(3):627-40. |
83(1,1,1,3) | Details |
| 7541446 | Satoh J, Kim SU: Cytokines and growth factors induce HSP27 phosphorylation in human astrocytes. J Neuropathol Exp Neurol. 1995 Jul;54(4):504-12. The level of HSP27 phosphorylation was elevated greatly after a 30 minute exposure to heat shock, sodium arsenite, interleukin-1 (IL-1 alpha and IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) with an increased expression of a diphosphorylated "c" isoform. |
31(0,1,1,1) | Details |
| 8572246 | Wong HR, Finder JD, Wasserloos K, Pitt BR: Expression of iNOS in cultured rat pulmonary artery smooth muscle cells is inhibited by the heat shock response. Am J Physiol. 1995 Dec;269(6 Pt 1):L843-8. We hypothesized that interleukin-1 beta (IL-1 beta)-mediated inducible synthase (iNOS) gene expression would be inhibited after induction of the heat shock response in cultured rat pulmonary artery smooth muscle cells (RPASMC). Exposure of RPASMC to sodium arsenite or heat led to expression of heat shock protein-70 (HSP-70) in a time- and concentration-dependent manner. |
3(0,0,0,3) | Details |
| 10543471 | LoCicero J 3rd, Xu X, Zhang L: Heat shock protein suppresses the senescent lung cytokine response to acute endotoxemia. Ann Thorac Surg. 1999 Oct;68(4):1150-3. METHODS: A dose-response and time-response curve for sodium arsenite (SA) induction of HSP was constructed. After 4 hours, lungs were harvested and Interleukin-1beta mRNA was assayed by Northern blot and semi-quantified by densitometry. |
2(0,0,0,2) | Details |
| 16507463 | Su PF, Hu YJ, Ho IC, Cheng YM, Lee TC: Distinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its methylated trivalent metabolites. Environ Health Perspect. 2006 Mar;114(3):394-403. This study systematically evaluated the effect of chronic treatment with sodium arsenite (iAs (III)), monomethylarsonous acid (MMA (III)), and dimethylarsinous acid (DMA (III)) on immortalized human uroepithelial cells (SV-HUC-1 cells) using cDNA microarray. Of the genes affected by all three arsenicals, only one, that coding for interleukin-1 receptor, type II, showed enhanced expression, a finding confirmed by the reduced increase in NF-kappaB (nuclear factor kappa B) activity seen in response to interleukin-1beta in iAs (III)-exposed cells. |
1(0,0,0,1) | Details |
| 8665897 | Meier R, Rouse J, Cuenda A, Nebreda AR, Cohen P: Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells. Eur J Biochem. 1996 Mar 15;236(3):796-805. In PC12 cells, the same two upstream activators, SAP kinase kinase-1 (SAPKK-1) and SAPKK-2 were activated after exposure to osmotic shock, ultraviolet irradiation or the protein synthesis inhibitor anisomycin, and more weakly in response to sodium arsenite. SAPKK-4 was the only SAP kinase-1 activator induced by interleukin-1 or ultraviolet irradiation, while two SAP kinase-1 activators, SAPKK-1 and SAPKK-5, were induced by osmotic shock or anisomycin. |
1(0,0,0,1) | Details |
| 17879257 | Perez DS, Handa RJ, Yang RS, Campain JA: Gene expression changes associated with altered growth and differentiation in benzo [a] pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508. These studies confirmed increased mRNA levels in NHEK by BaP of alpha-integrin binding protein 63 (AIBP63) (2.48-fold), - and interferon-inducible protein (IFIT5) (2.74-fold), interleukin-1 alpha (IL1A) (2.64-fold), interleukin-1 beta (IL1B) (2.84-fold) and Ras guanyl releasing protein 1 (RASGRP1) (3.14-fold). |
1(0,0,0,1) | Details |
| 8903404 | de Vera ME, Kim YM, Wong HR, Wang Q, Billiar TR, Geller DA: Heat shock response inhibits cytokine-inducible synthase expression in rat hepatocytes. Hepatology. 1996 Nov;24(5):1238-45. Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR. In the absence of the HSR, combinations of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) stimulated high levels of NOS2 mRNA and (NO) synthesis. |
1(0,0,0,1) | Details |
| 7858064 | Vietor I, Vilcek J: Pathways of heat shock protein 28 phosphorylation by TNF in human fibroblasts. Lymphokine Cytokine Res. 1994 Oct;13(5):315-23. Treatment of human diploid FS-4 fibroblasts with TNF or IL-1 led to a rapid increase in the phosphorylation of a approximately 28-kDa protein. Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. |
1(0,0,0,1) | Details |
| 9671371 | Swank GM, Lu Q, Xu DZ, Michalsky M, Deitch EA: Effect of acute-phase and heat-shock stress on apoptosis in intestinal epithelial cells (Caco-2). Crit Care Med. 1998 Jul;26(7):1213-7. OBJECTIVES: a) To determine if the sequence of exposure of intestinal epithelial cells to heat-shock or acute-phase stimuli would affect whether cellular protection or injury would occur; and b) to determine if the effects of a thermally induced heat-shock response can be mimicked by sodium arsenite, a nonthermal inducer of the heat-shock response. However, Caco-2 cells exposed to the cytokines IL-1beta and IL-6 had a significantly higher rate of apoptosis (22.1%, p < .01 vs. other groups). |
1(0,0,0,1) | Details |
| 11078701 | Kasai K, Banba N, Hishinuma A, Matsumura M, Kakishita H, Matsumura M, Motohashi S, Sato N, Hattori Y: 15-Deoxy-Delta (12,14)-prostaglandin J (2) facilitates thyroglobulin production by cultured human thyrocytes. Am J Physiol Cell Physiol. 2000 Dec;279(6):C1859-69. On the other hand, sodium arsenite, a known activator of the stress response pathway, induced HO-1 mRNA expression but lacked a promoting effect on TG production. |
0(0,0,0,0) | Details |