| Name | glucocorticoid receptor |
|---|---|
| Synonyms | GCCR; GCR; GR; GRL; Glucocorticoid receptor; NR3C1; Glucocorticoid receptors |
| Name | sodium arsenite |
|---|---|
| CAS | sodium arsenenite |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1597467 | Chakraborti PK, Garabedian MJ, Yamamoto KR, Simons SS Jr: Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors. J Biol Chem. 1992 Jun 5;267(16):11366-73. The involvement of a vicinally spaced dithiol group in steroid binding to the glucocorticoid receptor has been deduced from experiments with the thiol-specific reagent methyl methanethiolsulfonate and the vicinal dithiol-specific reagent sodium arsenite. |
33(0,1,1,3) | Details |
| 15906006 | Willemsen P, Scippo ML, Maghuin-Rogister G, Martial JA, Muller M: Enhancement of steroid receptor-mediated transcription for the development of highly responsive bioassays. Anal Bioanal Chem. 2005 Jun;382(4):894-905. Epub 2005 May 20. Sodium arsenite-induced chemical stress leads to a substantial and specific increase in the glucocorticoid receptor-mediated transcription, resulting in maximal stimulations of more than 2000-fold by the agonist dexamethasone. |
31(0,1,1,1) | Details |
| 1730584 | Sanchez ER: Heat shock induces translocation to the nucleus of the unliganded glucocorticoid receptor. J Biol Chem. 1992 Jan 5;267(1):17-20. A similar shift to nuclear localization for unliganded glucocorticoid receptor is noted in L929 and WCL2 cells subjected to chemical shock (sodium arsenite). |
11(0,0,1,6) | Details |
| 8180104 | Cavanaugh AH, Simons SS Jr: Factor-assisted DNA binding as a possible general mechanism for steroid receptors. J Steroid Biochem Mol Biol. 1994 Apr;48(5-6):433-46. We previously reported that activated glucocorticoid receptor-steroid complexes from rat HTC cell cytosol exist as at least two sub-populations, one of which requires a low molecular weight (700-3000 Da) factor (s) for binding to DNA. |
3(0,0,0,3) | Details |
| 8052262 | Sanchez ER, Hu JL, Zhong S, Shen P, Greene MJ, Housley PR: Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock. Mol Endocrinol. 1994 Apr;8(4):408-21. This potentiation of hormone-induced MMTV-CAT expression was dependent on the magnitude of the stress event and on the Dex concentration, with maximal increases observed for 1 microM Dex after 2 h at 43 C or 2 h at 200 microM sodium arsenite. |
2(0,0,0,2) | Details |
| 8274442 | Shen P, Xie ZJ, Li H, Sanchez ER: Glucocorticoid receptor conversion to high affinity nuclear binding and transcription enhancement activity in Chinese hamster ovary cells subjected to heat and chemical stress. J Steroid Biochem Mol Biol. 1993 Dec;47(1-6):55-64. |
2(0,0,0,2) | Details |
| 14673132 | Wadekar SA, Li D, Sanchez ER: Agonist-activated glucocorticoid receptor inhibits binding of heat shock factor 1 to the heat shock protein 70 promoter in vivo. Mol Endocrinol. 2004 Mar;18(3):500-8. Epub 2003 Dec 12. Dexamethasone inhibited HSF1 binding at the Hsp70 promoter in response to heat or chemical shock (sodium arsenite). |
2(0,0,0,2) | Details |
| 2266108 | Sanchez ER: Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes. J Biol Chem. 1990 Dec 25;265(36):22067-70. Induction of p56 also occurs in IM-9 cells subjected to chemical stress (sodium arsenite). Chem. 265, 10740-10745), while a smaller version of this protein (p56) interacts with glucocorticoid receptors in human IM-9 cell cytosols (Sanchez, E. |
2(0,0,0,2) | Details |
| 9222605 | Hu JL, Guan XJ, Sanchez ER: Enhancement of glucocorticoid receptor-mediated gene expression by cellular stress: evidence for the involvement of a heat shock-initiated factor or process during recovery from stress. Cell Stress Chaperones. 1996 Sep;1(3):197-205. Treatment of LMCAT2 cells with 1 microM dexamethasone for 2 h before heat or chemical shock (sodium arsenite) resulted in the same delayed onset pattern for the HSPE. |
2(0,0,0,2) | Details |
| 11786389 | Boone AN, Ducouret B, Vijayan MM: Glucocorticoid-induced release is abolished in trout hepatocytes with elevated hsp70 content. J Endocrinol. 2002 Jan;172(1):R1-5. Exposure of hepatocytes to either heat shock (HS;+15 degrees C) or sodium arsenite (50 microM) did not affect cell viability, but resulted in significantly higher hsp70 levels over a 24 h recovery period. This lack of glucocorticoid responsiveness corresponded with lower glucocorticoid receptor protein levels. |
1(0,0,0,1) | Details |
| 1692739 | Cavanaugh AH, Simons SS Jr: Glucocorticoid receptor binding to calf thymus DNA. 2. Biochemistry. 1990 Jan 30;29(4):996-1002. We find that sodium arsenite inhibits only the DNA binding of those complexes that require factor. |
1(0,0,0,1) | Details |
| 11198361 | Hauser GJ, Wasserloos K, Dayao EK, Pitt BR: Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat. Shock. 2001 Jan;15(1):73-6. |
0(0,0,0,0) | Details |
| 2226332 | Chakraborti PK, Hoeck W, Groner B, Simons SS Jr: Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor. Endocrinology. 1990 Nov;127(5):2530-9. Our previous studies with the thiol-specific reagent methyl methanethiolsulfonate (MMTS) and the vicinal dithiol-specific reagent sodium arsenite have established that 2 spatially close thiols (i.e. vicinal dithiols) are involved in steroid binding to the intact 98 K rat glucocorticoid receptor. |
82(1,1,1,2) | Details |