| Name | calmodulin |
|---|---|
| Synonyms | CALM; CAM; CALM 1; CALM 2; CALM 3; CALM1; CALM2; CALM3… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16565963 | Wang BW, Liao WN, Chang CT, Wang SJ: Facilitation of release by involves the activation of a Ca2+/calmodulin signaling pathway in rat prefrontal cortex nerve terminals. Synapse. 2006 Jun 15;59(8):491-501. We found that significantly potentiated 4-aminopyridine (4AP)-evoked release, and this potentiatory effect was mimicked by the selective alpha7 nicotinic receptor agonist and was blocked by the selective alpha7 nicotinic receptor antagonist methyllycaconitine, indicating its mediation by alpha7 nicotinic receptors. |
2(0,0,0,2) | Details |
| 19046383 | Padmanabhan S, Lambert NA, Prasad BM: Activity-dependent regulation of the dopamine transporter is mediated by Ca (2+)/calmodulin-dependent protein kinase signaling. Eur J Neurosci. 2008 Nov;28(10):2017-27. Sustained changes in neuronal activity caused by tetrodotoxin and 4-aminopyridine altered the uptake and abundance of dopamine transporter and its mRNA in rat mesencephalic cultures. |
2(0,0,0,2) | Details |
| 14976250 | Bush E, Fielitz J, Melvin L, Martinez-Arnold M, McKinsey TA, Plichta R, Olson EN: A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2870-5. Epub 2004 Feb 19. The calmodulin-dependent phosphatase calcineurin, regulates growth and gene expression of striated muscles. In a high-throughput screen for small molecules capable of regulating MCIP1 expression in muscle cells, we identified a unique 4-aminopyridine derivative exhibiting an embedded partial structural motif of |
1(0,0,0,1) | Details |
| 16183639 | Lenz G, Avruch J: Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. . J Biol Chem. 2005 Nov 18;280(46):38121-4. Epub 2005 Sep 22. Thus the mTOR-S6K pathway in neurons, a critical component of the late phase of LTP, is activated by glutamatergic stimulation in a /calmodulin-dependent fashion through a pool controlled by postsynaptic voltage-dependent channels, whereas sustained stimulation of extrasynaptic glutamate receptors is inhibitory. After 12 days in culture, the response to direct glutamatergic activation is attenuated but can be uncovered by suppression of interneurons with bicuculline in the presence of the weak K (+) channel blocker 4-aminopyridine (4-AP). |
1(0,0,0,1) | Details |
| 11588168 | Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC Jr, Greengard P, Czernik AJ: Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent release in isolated nerve terminals. J Neurosci. 2001 Oct 15;21(20):7944-53. We demonstrate that, in vitro, phosphorylation sites 1, 2, and 3 of synapsin I (P-site 1 phosphorylated by cAMP-dependent protein kinase; P-sites 2 and 3 phosphorylated by Ca (2+)-calmodulin-dependent protein kinase II) were excellent substrates for protein phosphatase 2A, whereas P-sites 4, 5, and 6 (phosphorylated by mitogen-activated protein kinase) were efficiently dephosphorylated only by Ca (2+)-calmodulin-dependent protein phosphatase 2B-calcineurin. |
1(0,0,0,1) | Details |
| 12630545 | Jones RL, Shum WW, Gurney AM: Synergism between prostanoids and other vasoactive agents. J Card Surg. 2002 Sep-Oct;17(5):436-8. In contrast, the other agents, including 4-AP, direct a non-L-type channel source of Ca2+ to the calmodulin-myosin light chain arm. In contrast, threshold sulprostone responses were dramatically enhanced in the presence of established small contractions to (alpha1-adrenoceptor agonist), U-46619 (TP agonist), cyclopiazonic acid (sarcoplasmic Ca2+ pump inhibitor), and 4-aminopyridine (4-AP, Kv channel blocker). |
1(0,0,0,1) | Details |
| 18845540 | Tauskela JS, Fang H, Hewitt M, Brunette E, Ahuja T, Thivierge JP, Comas T, Mealing GA: Elevated synaptic activity preconditions neurons against an in vitro model of ischemia. J Biol Chem. 2008 Dec 12;283(50):34667-76. Epub 2008 Oct 9. Specifically, exposing cultures to a K (+)-channel blocker, 4-aminopyridine (20-2500 microm), and a (A) receptor antagonist, bicuculline (50 microm) (4-AP/bic), for 1-2 days resulted in potent tolerance to normally lethal OGD applied up to 3 days later. Inhibiting ERK1/2 or Ca (2+)/calmodulin-dependent protein kinases (CaMKs) also reduced Ca (2+) spiking and OGD tolerance. |
1(0,0,0,1) | Details |
| 14614906 | Murray KD, Isackson PJ, Jones EG: N-methyl-D-aspartate receptor dependent transcriptional regulation of two /calmodulin-dependent protein kinase type II isoforms in rodent cerebral cortex. Neuroscience. 2003;122(2):407-20. Organotypic cortical slice cultures treated with bicuculline and 4-aminopyridine to induce seizure activity also showed a downregulation of CaMKII-alpha mRNA and an upregulation of CaMKII-delta mRNA. |
1(0,0,0,1) | Details |
| 15505083 | Hund TJ, Rudy Y: Rate dependence and regulation of action potential and transient in a canine cardiac ventricular cell model. Circulation. 2004 Nov 16;110(20):3168-74. Epub 2004 Oct 25. METHODS AND RESULTS: The Ca2+/calmodulin-dependent protein kinase (CaMKII) regulatory pathway was integrated into the model, which included a novel Ca2+-release formulation, Ca2+ subspace, dynamic handling, and formulations for major ion currents based on canine ventricular data. |
1(0,0,0,1) | Details |
| 16643405 | Wang Y, Cheng J, Tandan S, Jiang M, McCloskey DT, Hill JA: Transient-outward K+ channel inhibition facilitates L-type Ca2+ current in heart. J Cardiovasc Electrophysiol. 2006 Mar;17(3):298-304. Here, we investigated the effects of I (to) channel blockers, 4-aminopyridine (4-AP) and heteropodatoxin-2 (HpTx2), on I (Ca) in cardiac ventricular myocytes. Measurements of Ca2+/calmodulin-dependent protein kinase (CaMKII) activity revealed significant increases in cells treated with 4-AP. |
1(0,0,0,1) | Details |
| 10611476 | Waring M, Drappatz J, Weichel O, Seimetz P, Sarri E, Bockmann I, Kempter U, Valeva A, Klein J: Modulation of neuronal phospholipase D activity under depolarizing conditions. FEBS Lett. 1999 Dec 24;464(1-2):21-4. We here report that prolonged depolarization of rat hippocampal slices by potassium chloride (KCl) or 4-aminopyridine inhibited PLD activity. Inhibition of /calmodulin kinase II (CaMKII) which positively modulates synaptosomal PLD activity [Sarri et al. (1998) FEBS Lett. 440, 287-290] by KN-62 caused a further reduction of PLD activity in depolarized synaptosomes. |
1(0,0,0,1) | Details |