Protein Information

Name beta 3 adrenoceptors
Synonyms ADRB 3; ADRB3; ADRB3R; B3AR; BETA3AR; Beta 3 adrenergic receptor; Beta 3 adrenoceptor; Beta 3 adrenoreceptor…

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
14727522 Horinouchi T, Tanaka Y, Koike K: [beta-adrenoceptor subtypes involved in relaxations of guinea-pig gastrointestinal smooth muscles: distribution and signaling pathway of beta 3-adrenoceptors]. Nippon Yakurigaku Zasshi. 2003 Nov;122 Suppl:54P-56P.

These results indicate that beta 3-adrenoceptors play a primary role in relaxations of guinea-pig gastrointestinal smooth muscles and 4-aminopyridine-sensitive Kv channels participate in cAMP-independent smooth muscle relaxations in response to the activation of beta 3-adrenoceptors.
118(1,2,2,8) Details
12595962 Horinouchi T, Tanaka Y, Koike K: Evidence for the primary role for 4-aminopyridine-sensitive K (v) channels in beta (3)-adrenoceptor-mediated, cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles. Naunyn Schmiedebergs Arch Pharmacol. 2003 Feb;367(2):193-203. Epub 2003 Jan 14.
67(0,2,2,7) Details
12491798 Horinouchi T, Tanaka Y, Koike K: [Beta 3-adrenoceptor-mediated relaxation of guinea-pig gastric funds smooth muscle: cAMP-independent characteristics and a primary role of 4-aminopyridine-sensitive voltage-dependent K+ (Kv) channels]. Nippon Yakurigaku Zasshi. 2002 Nov;120(1):109P-111P.
41(0,1,2,6) Details
12208771 Rautureau Y, Toumaniantz G, Serpillon S, Jourdon P, Trochu JN, Gauthier C: Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway. Br J Pharmacol. 2002 Sep;137(2):153-61.

In addition, iberotoxin (0.1 microM), glibenclamide (1 microM) and 4-aminopyridine (1 mM), selective potassium channels blockers of K (Ca), K (ATP), and K (v) respectively, decreased the SR 58611A-mediated relaxation. 5.
1(0,0,0,1) Details