| Name | mitogen activated protein kinase (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15034129 | Daniel H, Rancillac A, Crepel F: Mechanisms underlying cannabinoid inhibition of presynaptic Ca2+ influx at parallel fibre synapses of the rat cerebellum. J Physiol. 2004 May 15;557(Pt 1):159-74. Epub 2004 Mar 19. The present study demonstrates that the molecular mechanisms underlying the CB1 inhibitory effect involve the activation of the PTX-sensitive G (i)/G (o) subclass of G proteins, independently of any direct effect on presynaptic Ca (2+) channels (N, P/Q and R (SNX-482-sensitive) types) or on adenylate cyclase or MAPK activity, but do require the activation of G protein-gated inwardly rectifying (Ba (2+)- and tertiapin Q-sensitive) K (+) channels, in addition to 4-aminopyridine-sensitive K (+) channels. |
82(1,1,1,2) | Details |
| 17397832 | Pan Z, Capo-Aponte JE, Zhang F, Wang Z, Pokorny KS, Reinach PS: Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation. Exp Eye Res. 2007 May;84(5):978-90. Epub 2007 Feb 11. Similar declines occurred with either a high-K+ (20 mM) supplemented solution or the K+ channel inhibitor 4-aminopyridine. |
3(0,0,0,3) | Details |
| 20044444 | Gao L, Li Y, Schultz HD, Wang WZ, Wang W, Finch M, Smith LM, Zucker IH: Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H945-55. Epub 2009 Dec 31. Employing this cell line, we also found that the ANG II-induced inhibition of Kv4.3 mRNA expression was attenuated by the scavenger Tempol and the p38 MAPK inhibitor SB-203580. In intact animals, we found that microinjection of the voltage-gated potassium channel blocker, 4-aminopyridine, into the RVLM evoked a sympathoexcitation and hypertension in both normal and CHF rats. |
2(0,0,0,2) | Details |
| 20193678 | Chang Y, Wang SJ: Hypericin, the active component of St. Eur J Pharmacol. 2010 Mar 1. John's wort, inhibits release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway.. Result showed that hypericin inhibited the release of evoked by 4-aminopyridine in a concentration-dependent manner. |
2(0,0,0,2) | Details |
| 12680846 | Aimond F, Fauconnier J, Donadille D, Vassort G: The p42/44mitogen-activated protein kinase inhibitor PD 98059, but not U 0126, increases a K+ current in cardiomyocytes. Clin Exp Pharmacol Physiol. 2003 Apr;30(4):273-7. The effects of the mitogen-activated protein kinase (MAPK) inhibitors PD 98059 and U 0126, useful tools to investigate MAPK involvement in intracellular signal transduction pathways, were assessed on cardiomyocytes. 2. |
2(0,0,0,2) | Details |
| 16020659 | Grishin A, Ford H, Wang J, Li H, Salvador-Recatala V, Levitan ES, Zaks-Makhina E: Attenuation of apoptosis in enterocytes by blockade of channels. Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G815-21. Epub 2005 Jul 14. Blockade of K+ efflux with tetraethylammonium, 4-aminopyridine, stromatoxin, chromanol 293B, and the recently described K+ channel inhibitor 48F10 prevents DNA fragmentation, caspase activation, release of cytochrome c from mitochondria, and loss of mitochondrial membrane potential. Apoptotic K+ efflux critically depends on activation of p38 MAPK. |
1(0,0,0,1) | Details |
| 15800056 | Guo TB, Lu J, Li T, Lu Z, Xu G, Xu M, Lu L, Dai W: Insulin-activated, K+-channel-sensitive Akt pathway is primary mediator of ML-1 cell proliferation. Am J Physiol Cell Physiol. 2005 Aug;289(2):C257-63. Epub 2005 Mar 30. Here we report that suppression of a voltage-gated K (+) channel with 4-aminopyridine (4-AP), barium, and tetraethylammonium inhibited both EGF- and insulin-stimulated myeloblastic leukemia ML-1 cell proliferation in a concentration-dependent manner. Both MAPK/ERK and Akt pathways are known to mediate cell proliferative signals of a variety of growth factors including insulin. |
1(0,0,0,1) | Details |
| 12612011 | Nunez A, Carro E, Torres-Aleman I: Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons. J Neurophysiol. 2003 Jun;89(6):3008-17. Epub 2003 Feb 5. Significantly, the increased excitability evoked by IGF-I in the DCN cells depends both in vivo and in vitro, on activation of p38 mitogen-activated protein kinase (MAPK), a Ser-kinase known to modulate K+ channel activity. |
1(0,0,0,1) | Details |
| 15086522 | Merlo D, Cifelli P, Cicconi S, Tancredi V, Avoli M: 4-Aminopyridine-induced epileptogenesis depends on activation of mitogen-activated protein kinase ERK. J Neurochem. 2004 May;89(3):654-9. Extracellular signal-regulated kinases such as ERK1 [p44 mitogen-activated protein kinase (MAPK)] and ERK2 (p42 MAPK) are activated in the CNS under physiological and pathological conditions such as ischemia and epilepsy. |
1(0,0,0,1) | Details |
| 18037462 | Cheng YC, Wang JJ, Chang LS: B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon. 2008 Feb;51(2):304-15. Epub 2007 Oct 13. Moreover, an activation of p38 MAPK was associated with the cytotoxicity of beta-Bgt. MK801 (an NMDA receptor antagonist), antibodies against NMDA receptor and 4-aminopyridine (a potassium channel blocker) markedly reduced the cytotoxic effects of beta-Bgt, B chain and catalytically inactivated beta-Bgt. |
1(0,0,0,1) | Details |
| 17093087 | Franciosi S, Ryu JK, Choi HB, Radov L, Kim SU, McLarnon JG: Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. J Neurosci. 2006 Nov 8;26(45):11652-64. Chronic exposure of human microglia to Abeta (1-42) led to enhanced p38 mitogen-activated protein kinase and nuclear factor kappaB expression with factors inhibited by 4-AP. |
1(0,0,0,1) | Details |
| 17322023 | Moritz A, Gust R, Pertz HH: Characterization of the relaxant response to N,N'-dipropyl-1,2-bis (2,6-dichloro-4-hydroxyphenyl) ethylenediamine in porcine coronary arteries. J Pharmacol Exp Ther. 2007 May;321(2):699-706. Epub 2007 Feb 22. The relaxant response to 8 was unaffected by the estrogen receptor antagonist ICI 182,780 (7alpha-[9-[(4,4,5,5,5-pentafluoropentyl]-sulfinyl] nonyl]-estra-1,3,5 (10)- triene-3,17beta-diol) and K+ channel blockers, i.e., TEA, glibenclamide, and 4-aminopyridine. Furthermore, the vasodilatory effect of 8 was unaffected by the adenylyl cyclase inhibitor SQ 22536 [9-(tetrahydro-2-furanyl)- the guanylyl cyclase inhibitor ODQ [1H-[1,2,4] oxadiazolo [4,3-a] quinoxalin-1-one], the protein kinase A inhibitor KT 5720 [(9S,10S,12R)-2,3,9,10,11,12-hexahydro-10--9-methyl-1-oxo-9,12-epox y-1H-diindolo [1,2,3-fg: 3',2',1'-kl] pyrrolo [3,4-i][1,6] benzodiazocine-10-carboxylic acid hexyl ester], the protein kinase G inhibitor KT 5823 [(9S,10R,12R)-2,3,9,10,11,12-hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12- epoxy-1H-diindolo [1,2,3-fg:3',2',1'-kl] pyrrolo [3,4-i][1,6] benzodiazocine-1 0-carboxylic acid methyl ester], and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB 203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)- . |
1(0,0,0,1) | Details |
| 11588168 | Jovanovic JN, Sihra TS, Nairn AC, Hemmings HC Jr, Greengard P, Czernik AJ: Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent release in isolated nerve terminals. J Neurosci. 2001 Oct 15;21(20):7944-53. We demonstrate that, in vitro, phosphorylation sites 1, 2, and 3 of synapsin I (P-site 1 phosphorylated by cAMP-dependent protein kinase; P-sites 2 and 3 phosphorylated by Ca (2+)-calmodulin-dependent protein kinase II) were excellent substrates for protein phosphatase 2A, whereas P-sites 4, 5, and 6 (phosphorylated by mitogen-activated protein kinase) were efficiently dephosphorylated only by Ca (2+)-calmodulin-dependent protein phosphatase 2B-calcineurin. |
1(0,0,0,1) | Details |