Protein Information

Name cysteine conjugate beta lyase
Synonyms CCBL 1; CCBL1; CCBL1 protein; Cysteine conjugate beta lyase; Cysteine S conjugate beta lyase; GTK; Glutamine phenylpyruvate aminotransferase; Glutamine transaminase K…

Compound Information

Name propachlor
CAS

Reference List

PubMed Abstract RScore(About this table)
6673379 Larsen GL, Larson JD, Gustafsson JA: Cysteine conjugate beta-lyase in the gastrointestinal bacterium Fusobacterium necrophorum. Xenobiotica. 1983 Nov;13(11):689-700.

This enzyme catalyses the cleavage of the thioether linkage in cysteine conjugates of the following S-alkyl- or S-aryl-linked compounds: cysteine conjugate of propachlor (2-S-cysteinyl-N-isopropylacetanilide); 1,2-dihydro-1-hydroxy-2-S-cysteinylnaphthalene and S-(2-benzothiazolyl) cysteine. 2-Mercapto-N-isopropylacetanilide, pyruvic acid and ammonia were produced from the beta-lyase cleavage of the cysteine conjugate of propachlor in equimolar ratios.
2(0,0,0,2) Details
3687061 Aschbacher PW, Struble CB: Evidence for involvement of non-biliary excretion into the intestines in the formation of methylsulphonyl-containing metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by swine and rats. Xenobiotica. 1987 Sep;17(9):1047-55.

It is concluded that after oral administration of propachlor to rats and swine, glutathione (GSH) conjugation and cysteine conjugate beta-lyase activity in the enteric flora are involved in formation of CH3SO2 metabolites.
81(1,1,1,1) Details
4024656 Larsen GL: Distribution of cysteine conjugate beta-lyase in gastrointestinal bacteria and in the environment. Xenobiotica. 1985 Mar;15(3):199-209.

These bacterial cysteine conjugate beta-lyases catalyse the cleavage of the thioether linkage of both an S-alkyl- and an S-aryl-linked cysteine conjugate (2-S-cysteinyl-N-isopropylacetanilide (cysteine conjugate of propachlor) and S-(2-benzothiazolylcysteine), respectively).
35(0,1,1,5) Details
2219963 Bakke JE, Davison KL, Larsen GL: Evidence for the absence of cysteine S-conjugate N-acetyltransferase activity in the metabolism of propachlor, naphthalene, and dichlobanil in calves. Xenobiotica. 1990 Aug;20(8):801-7.

0(0,0,0,0) Details