| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10632067 | Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR: Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities. Bioorg Med Chem. 1999 Nov;7(11):2569-75. |
63(0,2,2,3) | Details |
| 15003280 | Harrison PK, Tattersall JE, Clement RA: Periodic orbit analysis reveals subtle effects of atropine on epileptiform activity in the guinea-pig hippocampal slice. Neurosci Lett. 2004 Mar 11;357(3):183-6. We have used a recently developed mathematical technique based on periodic orbit analysis to investigate the effect of atropine (a muscarinic antagonist) on epileptiform activity induced by soman (an irreversible acetylcholinesterase inhibitor), 4-aminopyridine (a K+ channel blocker) and 8-cyclopentyl-1,3-dipropylxanthine (an adenosine A1 receptor antagonist) in the guinea-pig hippocampal slice. |
31(0,1,1,1) | Details |
| 11256231 | Ogura H, Kosasa T, Kuriya Y, Yamanishi Y: Comparison of inhibitory activities of and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13. The derivatives showed moderate selectivity, while the 4-aminopyridine derivatives tacrine and ipidacrine showed no selectivity. |
6(0,0,0,6) | Details |
| 15496314 | Caricati-Neto A, D'angelo LC, Reuter H, Hyppolito Jurkiewicz N, Garcia AG, Jurkiewicz A: Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens. Eur J Pharmacol. 2004 Oct 25;503(1-3):191-201. A striking enhancement of twitches was also caused by charybdotoxin, a blocker of high-conductance Ca2+-activated K+ channels, and by 4-aminopyridine, a non-specific blocker of K+ channels; in addition, apamin, a blocker of small-conductance Ca2+-activated K+ channels, induced a lower potentiation. |
5(0,0,0,5) | Details |
| 19172815 | Ishigaki K, Murakami T, Ito Y, Yanagisawa A, Kodaira K, Shishikura K, Suzuki H, Hirayama Y, Osawa M: [Treatment approach to congenital myasthenic syndrome in a patient with acetylcholine receptor deficiency]. No To Hattatsu. 2009 Jan;41(1):37-42. While CMS patients have been reported worldwide, in Japan there have been only a few descriptions of adult CMS patients with acetylcholinesterase (AChE) deficiency and slow channel syndrome. |
2(0,0,0,2) | Details |
| 19593127 | Argov Z: Management of myasthenic conditions: nonimmune issues. Curr Opin Neurol. 2009 Oct;22(5):493-7. RECENT FINDINGS: Antisense compound inhibiting acetylcholine esterase has positive therapeutic effects during short-term administration, but further studies are needed to confirm its chronic effects. |
1(0,0,0,1) | Details |
| 16643949 | Amato MP, Portaccio E, Zipoli V: Are there protective treatments for cognitive decline in MS? . J Neurol Sci. 2006 Jun 15;245(1-2):183-6. Epub 2006 Apr 27. Small trials with pemoline, 4-aminopyridine and 3-4 aminopyridine have provided mainly negative results. Acetylcholinesterase inhibitors (AChEI) used to treat Alzheimer's disease (AD)-such as rivastigmine, and galantamine-have recently been tested in other cognitive disorders, including MS. |
1(0,0,0,1) | Details |
| 16805718 | Verschuuren JJ, Wirtz PW, Titulaer MJ, Willems LN, van Gerven J: Available treatment options for the management of Lambert-Eaton myasthenic syndrome. Expert Opin Pharmacother. 2006 Jul;7(10):1323-36. Several drugs are available for the symptomatic treatment of the disease, including aminopyridines or acetylcholinesterase inhibitors. |
1(0,0,0,1) | Details |
| 18023348 | Scipione L, De Vita D, Musella A, Flammini L, Bertoni S, Barocelli E: 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity. Bioorg Med Chem Lett. 2008 Jan 1;18(1):309-12. Epub 2007 Nov 19. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. |
1(0,0,0,1) | Details |
| 16135768 | Wen H, Brehm P: Paired motor neuron-muscle recordings in zebrafish test the receptor blockade model for shaping synaptic current. J Neurosci. 2005 Aug 31;25(35):8104-11. In contrast, blockade of motor neuron K channels by 4-aminopyridine prolonged the action potential and introduced a significant delay and slowing of evoked synaptic currents, demonstrating our ability to measured altered transmitter release with this system. |
0(0,0,0,0) | Details |