| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16020659 | Grishin A, Ford H, Wang J, Li H, Salvador-Recatala V, Levitan ES, Zaks-Makhina E: Attenuation of apoptosis in enterocytes by blockade of channels. Am J Physiol Gastrointest Liver Physiol. 2005 Nov;289(5):G815-21. Epub 2005 Jul 14. Blockade of K+ efflux with tetraethylammonium, 4-aminopyridine, stromatoxin, chromanol 293B, and the recently described K+ channel inhibitor 48F10 prevents DNA fragmentation, caspase activation, release of cytochrome c from mitochondria, and loss of mitochondrial membrane potential. |
31(0,1,1,1) | Details |
| 20164347 | Leveille F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE: Suppression of the intrinsic apoptosis pathway by synaptic activity. J Neurosci. 2010 Feb 17;30(7):2623-35. Puma expression is sufficient to induce cytochrome c loss and neuronal apoptosis. |
2(0,0,0,2) | Details |
| 11557592 | Krick S, Platoshyn O, McDaniel SS, Rubin LJ, Yuan JX: Augmented K (+) currents and mitochondrial membrane depolarization in pulmonary artery myocyte apoptosis. Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L887-94. The mitochondrial membrane depolarization would cause cytochrome c release, activate the cytosolic caspases, and induce apoptosis. Blockade of K (V) channels with 4-aminopyridine diminished I (K (V)) and markedly decreased the ST-mediated apoptosis. |
1(0,0,0,1) | Details |
| 16806301 | Hu CL, Liu Z, Zeng XM, Liu ZQ, Chen XH, Zhang ZH, Mei YA: 4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons. Neuropharmacology. 2006 Sep;51(4):737-46. Epub 2006 Jun 27. Furthermore, 4-AP significantly inhibited cytochrome c release and caspase-3 activity induced by low-K+/serum-free incubation. |
1(0,0,0,1) | Details |