| Name | SK3 |
|---|---|
| Synonyms | K3; KCNN 3; KCNN3; KCa2.3; SK3; SKCA 3; SKCA3; Small conductance calcium activated potassium channel protein 3… |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11378158 | Grunnet M, Jespersen T, Angelo K, Frokjaer-Jensen C, Klaerke DA, Olesen SP, Jensen BS: Pharmacological modulation of SK3 channels. Neuropharmacology. 2001 Jun;40(7):879-87. Brain slice studies commonly employ 4-aminopyridine (4-AP) to block voltage-dependent K+ channels or a methyl derivative of bicuculline, a blocker of -gated Cl- channels, in order to investigate the role of various synapses in specialized neural networks. |
5(0,0,0,5) | Details |
| 17121942 | Potier M, Joulin V, Roger S, Besson P, Jourdan ML, Leguennec JY, Bougnoux P, Vandier C: Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol Cancer Ther. 2006 Nov;5(11):2946-53. Patch-clamp recordings showed typical small-conductance Ca (2+)-activated K (+) channel-mediated currents sensitive to apamin, 4-aminopyridine, and tetraethylammonium. |
4(0,0,0,4) | Details |
| 17687001 | Bai X, Ma J, Pan Z, Song YH, Freyberg S, Yan Y, Vykoukal D, Alt E: Electrophysiological properties of human adipose tissue-derived stem cells. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1539-50. Epub 2007 Aug 8. RT-PCR results confirmed the presence of ion channels at the mRNA level: Kv1.1, Kv2.1, Kv1.5, Kv7.3, Kv11.1, and hEAG1, possibly encoding I (KDR); MaxiK, KCNN3, and KCNN4 for I (KCa); Kv1.4, Kv4.1, Kv4.2, and Kv4.3 for I (to) and hNE-Na for I (Na.TTX). The I (KDR) was inhibited by tetraethyl ammonium (TEA) and 4-aminopyridine (4-AP), which significantly reduced the proliferation of hASCs in a dose-dependent manner (P < 0.05), as suggested by bromodeoxyurindine (BrdU) incorporation. |
1(0,0,0,1) | Details |
| 17493598 | Yazdi HH, Janahmadi M, Behzadi G: The role of small-conductance Ca2+-activated K+ channels in the modulation of 4-aminopyridine-induced burst firing in rat cerebellar Purkinje cells. Brain Res. 2007 Jul 2;1156:59-66. Epub 2007 Apr 18. In the mammalian brain, 3 subunits (SK1-SK3) are expressed with different distributions. |
1(0,0,0,1) | Details |