Protein Information

Name myocardin related transcription factor A
Synonyms BSAC; MAL; MKL 1; MKL/myocardin like protein 1; MKL1; MKL1/RBM15 fusion gene; MRTF A; Megacaryocytic acute leukemia protein…

Compound Information

Name SMA
CAS sodium 2-chloroacetate

Reference List

PubMed Abstract RScore(About this table)
18337547 Elberg G, Chen L, Elberg D, Chan MD, Logan CJ, Turman MA: MKL1 mediates TGF-beta1-induced alpha-smooth muscle actin expression in human renal epithelial cells. Am J Physiol Renal Physiol. 2008 May;294(5):F1116-28. Epub 2008 Mar 12.

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19596799 Chan MW, Arora PD, Bozavikov P, McCulloch CA: FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin. J Cell Sci. 2009 Aug 1;122(Pt 15):2769-81. Epub 2009 Jul 13.


Force-induced nuclear translocation of MRTF-A, a transcriptional co-activator of SMA that is regulated by actin filaments, was also reduced by FAK knockdown.
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19893564 Du H, Wang X, Wu J, Qian Q: Phenylephrine induces elevated RhoA activation and smooth muscle alpha-actin expression in Pkd2+/- vascular smooth muscle cells. Hypertens Res. 2010 Jan;33(1):37-42. Epub 2009 Nov 6.


Myocardin-related transcription factor-A (MRTF-A) (SMA transcription coactivator) was localized by immunofluorescence, nuclear MRTF-A quantified by western analysis using nuclear extracts and SMA expression by luciferase reporter assay.
2(0,0,0,2) Details
20071339 Chan MW, Chaudary F, Lee W, Copeland JW, McCulloch CA: Force-induced myofibroblast differentiation through collagen receptors is dependent on mammalian diaphanous (mDia). J Biol Chem. 2010 Mar 19;285(12):9273-81. Epub 2010 Jan 13.


Force-induced nuclear translocation of MRTF-A, a transcriptional co-activator of SMA, was reduced 50% by mDia knockdown.
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20177148 Jeon ES, Heo SC, Lee IH, Choi YJ, Park JH, Choi KU, Park DY, Suh DS, Yoon MS, Kim JH: Ovarian Cancer-Derived Lysophosphatidic Acid Stimulates Secretion of VEGF and SDF-1a from Human Mesenchymal Stem Cells. Exp Mol Med. 2010 Feb 22.


LPA induced expression of myocardin and myocardin-related transcription factor-A, transcription factors involved in smooth muscle differentiation, in hASCs.
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