Protein Information

Name sulfotransferases (protein family or complex)
Synonyms sulfotransferase; sulfotransferases

Compound Information

Name sulfuric acid
CAS sulfuric acid

Reference List

PubMed Abstract RScore(About this table)
14754874 Glatt H, Meinl W: Use of genetically manipulated Salmonella typhimurium strains to evaluate the role of sulfotransferases and acetyltransferases in nitrofen mutagenicity. Carcinogenesis. 2004 May;25(5):779-86. Epub 2004 Jan 30.

Nitrofen is a nitroarene and as such might be activated to a mutagen via reduction to the corresponding hydroxylamine and subsequent formation of a reactive acetic or sulfuric acid ester.
2(0,0,0,2) Details
11950791 Meloche CA, Sharma V, Swedmark S, Andersson P, Falany CN: Sulfation of budesonide by human cytosolic sulfotransferase, dehydroepiandrosterone-sulfotransferase (DHEA-ST). Drug Metab Dispos. 2002 May;30(5):582-5.


This study describes the conjugation of budesonide by human cytosolic sulfotransferases (SULTs).
1(0,0,0,1) Details
18815351 Senggunprai L, Yoshinari K, Shimada M, Yamazoe Y: Involvement of ST1B subfamily of cytosolic sulfotransferase in kynurenine metabolism to form natriuretic xanthurenic acid sulfate. J Pharmacol Exp Ther. 2008 Dec;327(3):789-98. Epub 2008 Sep 24.


In the present study, we have investigated the sulfation of xanthurenic acid (XA) in mouse tissues to assess the contribution of specific sulfotransferases (STs) to the reaction.
1(0,0,0,1) Details
19382817 Monien BH, Frank H, Seidel A, Glatt H: Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. Chem Res Toxicol. 2009 Jun;22(6):1123-8.

HMF is inactive in in vitro genotoxicity tests using standard activating systems but is activated to a mutagen by sulfotransferases.
1(0,0,0,1) Details
16035375 Fuhr U, Kober S, Zaigler M, Mutschler E, Spahn-Langguth H: Rate-limiting biotransformation of triamterene is mediated by CYP1A2. . Int J Clin Pharmacol Ther. 2005 Jul;43(7):327-34.


OBJECTIVE: Triamterene (TA), a potassium-sparing diuretic, is extensively metabolized by hydroxylation in 4'-position and subsequent conjugation by cytosolic sulfotransferases.
1(0,0,0,1) Details