Protein Information

Name PP2
Synonyms NPY1RL; NPY6R; PP2; Y2B; Y6 encoding protein; neuropeptide Y receptor Y6 (pseudogene); Y6 encoding proteins; neuropeptide Y receptor Y6 (pseudogene)s

Compound Information

Name 4-aminopyridine
CAS 4-pyridinamine

Reference List

PubMed Abstract RScore(About this table)
12960777 Wang SJ: A role for Src kinase in the regulation of glutamate release from rat cerebrocortical nerve terminals. Neuroreport. 2003 Aug 6;14(11):1519-22.


In order to investigate the role of Src kinase on neurotransmmiter glutamate release, we studied the effect of PP2, an Src family tyrosine kinase-specific inhibitor, on depolarization-induced glutamate release.
3(0,0,0,3) Details
10890901 Sanna PP, Berton F, Cammalleri M, Tallent MK, Siggins GR, Bloom FE, Francesconi W: A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8653-7.


Spontaneous epileptiform discharges were induced in vitro in the CA3 region of rat hippocampal slices by superfusion with the potassium channel blocker 4-aminopyridine in Mg (2+)-free medium.
0(0,0,0,0) Details
16272889 Shyu KG, Jow GM, Lee YJ, Wang SJ: PP2 inhibits glutamate release from nerve endings by affecting vesicle mobilization. Neuroreport. 2005 Nov 28;16(17):1969-72.

Also, disruption of cytoskeleton organization with cytochalasin D occluded the inhibitory action of PP2 on 4-aminopyridine and ionomycin-evoked glutamate release.
35(0,1,1,5) Details