| Name | acetylcholine receptor (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | 4-aminopyridine |
|---|---|
| CAS | 4-pyridinamine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15145336 | Burke G, Cossins J, Maxwell S, Robb S, Nicolle M, Vincent A, Newsom-Davis J, Palace J, Beeson D: Distinct phenotypes of congenital acetylcholine receptor deficiency. Neuromuscul Disord. 2004 Jun;14(6):356-64. |
5(0,0,0,5) | Details |
| 14976404 | Shi H, Wang H, Li D, Nattel S, Wang Z: Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding K+ channels in canine atria with atrial fibrillation induced by experimental congestive heart failure. Cell Physiol Biochem. 2004;14(1-2):31-40. Whole-patch-clamp recordings showed that the current densities of IKACh (induced by 1 mM and IK4AP (induced by 1 mM 4-aminopyridine) were n45% and n55% lower, respectively, while that of IKM3 (induced by 10 mM was n75% higher, at a plateau voltage of 0 mV in atrial myocytes from CHF than those from healthy hearts. |
2(0,0,0,2) | Details |
| 19172815 | Ishigaki K, Murakami T, Ito Y, Yanagisawa A, Kodaira K, Shishikura K, Suzuki H, Hirayama Y, Osawa M: [Treatment approach to congenital myasthenic syndrome in a patient with acetylcholine receptor deficiency]. No To Hattatsu. 2009 Jan;41(1):37-42. |
2(0,0,0,2) | Details |
| 12213259 | Wong JY, Ross SA, McColl C, Massalas JS, Powney E, Finkelstein DI, Clark M, Horne MK, Berkovic SF, Drago J: Proconvulsant-induced seizures in alpha (4) nicotinic acetylcholine receptor subunit knockout mice. Neuropharmacology. 2002 Jul;43(1):55-64. We investigated the response of alpha (4) nAChR subunit knockout mice to the (GABA) receptor antagonists; pentylenetetrazole (PTZ) and bicuculline (BIC), the glutamate receptor agonist kainic acid (KA), the glycine receptor antagonist strychnine and the K (+) channel blocker 4-aminopyridine (4-AP). |
2(0,0,0,2) | Details |
| 17206662 | Sha SJ, Layzer RB: Myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient. Muscle Nerve. 2007 Jul;36(1):115-7. Antibodies to the acetylcholine receptor were found in her serum, but electrodiagnostic testing showed abnormalities typical of the Lambert-Eaton myasthenic syndrome (LEMS). |
1(0,0,0,1) | Details |
| 15036330 | Banwell BL, Ohno K, Sieb JP, Engel AG: Novel truncating RAPSN mutations causing congenital myasthenic syndrome responsive to 3,4-diaminopyridine. Neuromuscul Disord. 2004 Mar;14(3):202-7. Rapsyn is essential for clustering the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction. |
1(0,0,0,1) | Details |
| 12624181 | Urbano FJ, Piedras-Renteria ES, Jun K, Shin HS, Uchitel OD, Tsien RW: Altered properties of quantal neurotransmitter release at endplates of mice lacking P/Q-type Ca2+ channels. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3491-6. Epub 2003 Mar 6. Changes in presynaptic function were also associated with a significant reduction in the size of postsynaptic acetylcholine receptor clusters. |
1(0,0,0,1) | Details |
| 14529953 | Roshan-Milani S, Ferrigan L, Khoshnood MJ, Davies CH, Cobb SR: Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation. Epilepsy Res. 2003 Sep;56(1):51-65. Bath application of the potassium channel blocker 4-aminopyridine (4AP; 10-50 microM) resulted in the development of spontaneous epileptiform bursting activity in area CA3 that consisted of short duration (257+/-15 ms) field events occurring regularly at a frequency of 0.4+/-0.02 Hz. |
1(0,0,0,1) | Details |
| 16338999 | Bandyopadhyay S, Sutor B, Hablitz JJ: Endogenous enhances synchronized interneuron activity in rat neocortex. J Neurophysiol. 2006 Mar;95(3):1908-16. Epub 2005 Dec 7. Application of 4-aminopyridine (4-AP) along with EAA) receptor antagonists produces (GABAA) receptor-dependent synchronized activity in interneurons. Because interneurons in the neocortex are excited by nicotinic acetylcholine receptor (nAChR) agonists, may influence synchronization of these local neocortical interneuronal networks. |
1(0,0,0,1) | Details |
| 19166510 | Grilli M, Zappettini S, Zoli M, Marchi M: Pre-synaptic nicotinic and D receptors functionally interact on dopaminergic nerve endings of rat and mouse nucleus accumbens. J Neurochem. 2009 Mar;108(6):1507-14. Epub 2009 Feb 16. The aim of the present work was to investigate whether acetylcholine receptors (nAChRs) and (DA) autoreceptors, which are both able to modulate DA release, functionally interact on the same nerve endings. Both nicotinic agonists and 4-aminopyridine (4-AP) provoked [(3) H] DA release which was inhibited by quinpirole and blocked by sulpiride and raclopride. |
1(0,0,0,1) | Details |
| 10849677 | Shirahata M, Ishizawa Y, Rudisill M, Sham JS, Schofield B, Fitzgerald RS: sensitivity of cat petrosal ganglion neurons. . Adv Exp Med Biol. 2000;475:377-87. We investigated if neuronal nicotinic acetylcholine receptors (nAChRs) are localized in chemoreceptor afferent neurons in the cat petrosal ganglion (PG) and if excites chemoreceptor afferent neurons. Outward current was blocked by 4-aminopyridine (4-AP) and sometimes by atropine. |
1(0,0,0,1) | Details |
| 12649591 | Shi H, Yang B, Xu D, Wang H, Wang Z: Electrophysiological characterization of cardiac muscarinic acetylcholine receptors: different subtypes mediate different currents. Cell Physiol Biochem. 2003;13(2):59-74. Tetramethylammonium (0.5 mM) activated a K+ conductance with delayed rectifying properties (I (KM3)) and the currents were highly sensitive to 4-diphenylacetoxy-N-methylpiperidine methiodide (2 nM, an M3 receptor inhibitor). 4-aminopyridine (1 mM) induced a delayed rectifier-like current (I (K4AP)) which was selectively suppressed by tropicamide (200 nM, an M4 receptor blocker). |
1(0,0,0,1) | Details |
| 16135768 | Wen H, Brehm P: Paired motor neuron-muscle recordings in zebrafish test the receptor blockade model for shaping synaptic current. J Neurosci. 2005 Aug 31;25(35):8104-11. We used this preparation to test the recent proposal that open channel block of the acetylcholine receptor by modulates the kinetics and timing of transmission between nerve and muscle in larval zebrafish (Legendre et al., 2000). In contrast, blockade of motor neuron K channels by 4-aminopyridine prolonged the action potential and introduced a significant delay and slowing of evoked synaptic currents, demonstrating our ability to measured altered transmitter release with this system. |
1(0,0,0,1) | Details |