Protein Information

Name protein is
Synonyms ANX 2; p36; LIP 2; LIP2; ANX2; ANX2L4; ANX2P1; ANX2P2…

Compound Information

Name EXD
CAS

Reference List

PubMed Abstract RScore(About this table)
17024417 Blagburn JM: Co-factors and co-repressors of Engrailed: expression in the central nervous system and cerci of the cockroach, Periplaneta americana. Cell Tissue Res. 2007 Jan;327(1):177-87. Epub 2006 Sep 22.

In the first instar CNS, Exd protein is expressed in subsets of neurons (including dorsal unpaired medial neurons) in the thoracic ganglia, in the first two abdominal ganglia, and in neuromeres A8-A11 of the terminal ganglion.
6(0,0,1,1) Details
8857540 Mann RS, Abu-Shaar M: Nuclear import of the homeodomain protein extradenticle in response to Wg and Dpp signalling. Nature. 1996 Oct 17;383(6601):630-3.

Exd protein is predominantly nuclear in endoderm cells close to Dpp-and Wg-secreting cells of the visceral mesoderm, but is in the cytoplasm in more distant endoderm cells.
6(0,0,1,1) Details
9463350 Kurant E, Pai CY, Sharf R, Halachmi N, Sun YH, Salzberg A: Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS. Development. 1998 Mar;125(6):1037-48.

We also show that the HTH protein is present in extremely low levels in embryos lacking exd activity as compared to wild-type embryos.
6(0,0,1,1) Details
11755217 Ethell DW, Bossy-Wetzel E, Bredesen DE: Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro. Biochim Biophys Acta. 2001 Dec 19;1541(3):231-8.


We have found that during apoptosis human TNFRI protein is lost in a caspase-dependent manner.
1(0,0,0,1) Details
11684652 Waskiewicz AJ, Rikhof HA, Hernandez RE, Moens CB: Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development. 2001 Nov;128(21):4139-51.

Homeodomain-containing Hox proteins regulate segmental identity in Drosophila in concert with two partners known as Extradenticle (Exd) and Homothorax (Hth).
Previous results have demonstrated that the zygotically encoded Pbx4/Lazarus (Lzr) protein is required for segmentation of the zebrafish hindbrain and proper expression and function of Hox genes.
1(0,0,0,1) Details
9436985 Azpiazu N, Morata G: Functional and regulatory interactions between Hox and extradenticle genes. Genes Dev. 1998 Jan 15;12(2):261-73.


The homeobox gene extradenticle (exd) acts as a cofactor of Hox function both in Drosophila and vertebrates.
0(0,0,0,0) Details
7859741 Sun B, Hursh DA, Jackson D, Beachy PA: Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 1995 Feb 1;14(3):520-35.


Other factors are also required, including one that appears to act through homeodomain protein binding sites and may be encoded by extradenticle (exd).
0(0,0,0,0) Details
9671305 Gonzalez-Crespo S, Abu-Shaar M, Torres M, Martinez-A C, Mann RS, Morata G: Antagonism between extradenticle function and Hedgehog signalling in the developing limb. Nature. 1998 Jul 9;394(6689):196-200.

The Drosophila homeobox gene extradenticle (exd) encodes a highly conserved cofactor of Hox proteins. exd activity is regulated post-translationally by a mechanism involving nuclear translocation; only nuclear Exd protein is functional.
31(0,1,1,1) Details