| 12713833 |
Scozzafava A, Supuran CT: Hydroxyurea is a carbonic anhydrase inhibitor. . Bioorg Med Chem. 2003 May 15;11(10):2241-6.
The spectrum of the adduct of hydroxyurea with Co (II)-hCA II is similar to the spectra of tetrahedral adducts (such as those with sulfamide, acetazolamide or cyanamide), proving a direct interaction of the inhibitor molecule with the metal center of the enzyme, whose geometry remains tetrahedral.
This binding may be exploited for the design of both CA as well as matrix metalloproteinase (MMP) inhibitors, since hydroxyurea is the simplest compound incorporating a hydroxamate functionality in its molecule. |
1(0,0,0,1) |
Details |