Protein Information

Name beta actin
Synonyms ACTB; Actin beta; Beta actin; Beta cytoskeletal actin; PS1TP5BP1; Actin betas; Beta actins; Beta cytoskeletal actins

Compound Information

Name acrolein
CAS 2-propenal

Reference List

PubMed Abstract RScore(About this table)
19271284 Chung WG, Miranda CL, Stevens JF, Maier CS: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol. 2009 Apr;47(4):827-36.

Mass spectrometry-based proteomic analysis in combination with 2-alkenal-specific immunochemical detection identified beta-actin and protein disulfide isomerase as major putative targets of acrolein adduction.
31(0,1,1,1) Details
19709606 Chung WG, Miranda CL, Stevens JF, Maier CS: Hop proanthocyanidins induce apoptosis, protein carbonylation, and cytoskeleton disorganization in human colorectal adenocarcinoma cells via reactive oxygen species. Food Chem Toxicol. 2009 Jan 15.

Mass spectrometry-based proteomic analysis in combination with 2-alkenal-specific immunochemical detection identified beta-actin and protein disulfide isomerase as major putative targets of acrolein adduction.
31(0,1,1,1) Details
17570602 Mello CF, Sultana R, Piroddi M, Cai J, Pierce WM, Klein JB, Butterfield DA: Acrolein induces selective protein carbonylation in synaptosomes. Neuroscience. 2007 Jul 13;147(3):674-9. Epub 2007 Jun 14.

Proteomic analysis (two-dimensional electrophoresis followed by mass spectrometry) revealed that tropomyosin-3-gamma isoform 2, tropomyosin-5, beta-actin, mitochondrial Tu translation elongation factor (EF-Tu (mt)) and voltage-dependent anion channel (VDAC) were significantly carbonylated by acrolein.
6(0,0,1,1) Details
12392766 Butterfield DA, Castegna A, Lauderback CM, Drake J: Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging. 2002 Sep-Oct;23(5):655-64.

Two reactive products of lipid peroxidation are the alkenals, 4-hydroxynonenal (HNE) and 2-propenal (acrolein).
Creatine kinase (CK) and beta-actin have increased carbonyl groups, and Glt-1, a glutamate transporter, has increased binding of HNE in AD.
1(0,0,0,1) Details