| Name | myeloperoxidase |
|---|---|
| Synonyms | 38 kDa MYELOPEROXIDASE; MPO; Myeloperoxidase; Myeloperoxidase precursor; Peroxidase (Myeloperoxidase); Myeloperoxidases; Myeloperoxidase precursors; Peroxidase (Myeloperoxidase)s |
| Name | acrolein |
|---|---|
| CAS | 2-propenal |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9022075 | Anderson MM, Hazen SL, Hsu FF, Heinecke JW: Human neutrophils employ the myeloperoxidase- peroxide- system to convert -amino acids into and acrolein. J Clin Invest. 1997 Feb 1;99(3):424-32. |
86(1,1,1,6) | Details |
| 16126721 | Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW: Acrolein impairs ATP binding cassette transporter A1-dependent export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem. 2005 Oct 28;280(43):36386-96. Epub 2005 Aug 25. Lipid peroxidation and oxidation by myeloperoxidase are potential sources of acrolein during inflammation. |
81(1,1,1,1) | Details |
| 14522963 | Kawai Y, Furuhata A, Toyokuni S, Aratani Y, Uchida K: Formation of acrolein-derived 2'- adduct in an iron-induced carcinogenesis model. J Biol Chem. 2003 Dec 12;278(50):50346-54. Epub 2003 Sep 30. Acrolein is a representative carcinogenic found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidase-catalyzed amino acid oxidation. |
81(1,1,1,1) | Details |
| 12921788 | Al-Maghrebi MA, Al-Mulla F, Benov LT: induces apoptosis in a human breast cancer cell line. Arch Biochem Biophys. 2003 Sep 1;417(1):123-7. Activated phagocytes employ myeloperoxidase to generate and acrolein. |
31(0,1,1,1) | Details |
| 18203133 | Stevens JF, Maier CS: Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res. 2008 Jan;52(1):7-25. The main endogenous sources of acrolein are myeloperoxidase-mediated degradation of and amine oxidase-mediated degradation of and which may constitute a significant source of acrolein in situations of oxidative stress and inflammation. |
31(0,1,1,1) | Details |
| 19696094 | Conklin DJ, Haberzettl P, Lesgards JF, Prough RA, Srivastava S, Bhatnagar A: Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. J Pharmacol Exp Ther. 2009 Nov;331(2):456-69. Epub 2009 Aug 20. CY treatment also led to greater accumulation of myeloperoxidase-positive cells and specific protein-acrolein adducts in the bladder of GSTP-null than WT mice. |
6(0,0,1,1) | Details |
| 19418724 | Linares-Fernandez B, Alfieri AB: [Changes in prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. Invest Clin. 2009 Mar;50(1):23-33. |
6(0,0,1,1) | Details |
| 16267254 | Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS: Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 2005 Nov 1;112(18):2812-20. One theoretical source of reactive aldehydes is oxidation of common alpha-amino acids by myeloperoxidase (MPO) released by leukocytes. METHODS AND RESULTS: In studies with cell types found in vascular tissue, MPO-oxidation products of and (acrolein) were the most cytotoxic. |
1(0,0,0,1) | Details |
| 10484460 | Fukuda T, Kim DK, Chin MR, Hales CA, Bonventre JV: Increased group IV cytosolic phospholipase A2 activity in lungs of sheep after smoke inhalation injury. Am J Physiol. 1999 Sep;277(3 Pt 1):L533-42. Lung myeloperoxidase activity increased progressively with increased exposure to smoke. cPLA2 was identified in sheep neutrophils. Increased phospholipase A2 (PLA2) activity was measured in cytosolic fractions of lungs from sheep exposed to smoke from burning cotton or to synthetic smoke consisting of carbon and acrolein, a cotton smoke toxin. |
1(0,0,0,1) | Details |
| 19716872 | Lee JY, Kang HS, Park BE, Moon HJ, Sim SS, Kim CJ: Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene -induced colitis. J Ethnopharmacol. 2009 Nov 12;126(2):244-51. Epub 2009 Aug 28. MATERIALS AND METHODS: GJT orally given to mice before and after TNBS intoxication, and their clinical and morphological changes, myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in colon tissues, were evaluated on Day 8 post-TNBS. |
1(0,0,0,1) | Details |
| 11246141 | Nguyen H, Finkelstein E, Reznick A, Cross C, van der Vliet A: Cigarette smoke impairs neutrophil respiratory burst activation by -induced thiol modifications. Toxicology. 2001 Mar 7;160(1-3):207-17. Stimulation of neutrophils in the presence of CS resulted in a reduced oxidation and chlorination of HPA, suggesting inhibition of oxidase or myeloperoxidase (MPO), the two major enzymes involved in inflammatory oxidant formation. As alpha,beta-unsaturated aldehydes such as acrolein have been implicated in thiol modifications by CS, we exposed neutrophils to acrolein prior to stimulation, and observed inhibition of oxidase activation in relation to GSH depletion. |
1(0,0,0,1) | Details |