Protein Information

Name Rho kinase
Synonyms NY REN 35 antigen; P160ROCK; ROCK 1; ROCK1; ROK alpha; ROKa; ROKalpha; Rho associated coiled coil containing protein kinase 1…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
16527249 Jeon SB, Jin F, Kim JI, Kim SH, Suk K, Chae SC, Jun JE, Park WH, Kim IK: A role for Rho kinase in vascular contraction evoked by sodium fluoride. . Biochem Biophys Res Commun. 2006 Apr 28;343(1):27-33. Epub 2006 Feb 28.
15(0,0,2,5) Details
19277501 Je HD, Sohn UD: Inhibitory effect of genistein on agonist-induced modulation of vascular contractility. Mol Cells. 2009 Feb;27(2):191-8. Epub 2009 Feb 20.


An inactive analogue, daidzein, completely inhibited only fluoride-induced contraction regardless of endothelial function, suggesting some difference between the mechanisms of RhoA/Rho-kinase activators such as fluoride and thromboxane A (2).
3(0,0,0,3) Details
20221280 Yang E, Cho JY, Sohn UD, Kim IK: Calcium sensitization induced by sodium fluoride in permeabilized rat mesenteric arteries. Korean J Physiol Pharmacol. 2010 Feb;14(1):51-7. Epub 2010 Feb 28.

These results suggest that NaF is an activator of the Rho kinase signaling pathway during vascular contraction.
1(0,0,0,1) Details