Protein Information

Name insulin like growth factor I
Synonyms IBP1; MGF; IBP1; IGF 1; IGF IA; IGF IB; IGF1; IGFI…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
16194044 Okopien B, Krysiak R, Labuzek K, Herman ZS: [Anabolic therapy of osteoporosis] . Pol Merkur Lekarski. 2005 Jul;19(109):118-21.

In the present study we describe in details sodium fluoride, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), growth hormone, insulin-like growth factor I, and parathormone and its analogues, describing their mechanism of action and adverse effects.
81(1,1,1,1) Details
16124390 Okopien B, Krysiak R, Labuzek K, Herman ZS: [Anabolic therapy in osteoporosis--part 1] . Pol Merkur Lekarski. 2005 Jun;18(108):712-4.

In the present study we describe in details sodium fluoride, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), growth hormone, insulin-like growth factor I, and parathormone and its analogues, describing their mechanism of action and adverse effects.
81(1,1,1,1) Details
9510097 Yamaguchi M, Gao YH: Potent effect of zinc acexamate on bone components in the femoral-metaphyseal tissues of elderly female rats. Gen Pharmacol. 1998 Mar;30(3):423-7.

The effect of zinc acexamate (10 [-5] M) on the increase of alkaline phosphatase activity in the metaphyseal tissues was remarkable as compared with that of insulin (10 [-8] M), estrogen (10 [-9] M), insulin-like growth factor-I (10 [-8] M), transforming growth factor-beta (10 [-10] M), sodium fluoride (10 [-3] M), dexamethasone (10 [-7] M) and vitamin K2 (menaquinone-4; 10 [-5] M) with an effective concentration. 4.
6(0,0,1,1) Details
14713283 Pepene CE, Seck T, Diel I, Minne HW, Ziegler R, Pfeilschifter J: Influence of fluor salts, hormone replacement therapy and calcitonin on the concentration of insulin-like growth factor (IGF)-I, IGF-II and transforming growth factor-beta 1 in human iliac crest bone matrix from patients with primary osteoporosis. Eur J Endocrinol. 2004 Jan;150(1):81-91.

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9437512 Ammann P, Rizzoli R, Caverzasio J, Bonjour JP: Fluoride potentiates the osteogenic effects of IGF-I in aged ovariectomized rats. Bone. 1998 Jan;22(1):39-43.

However, fluoride has been shown to enhance the protein tyrosine phosphorylation of various constituents of intracellular signaling cascades in osteoblastic cells following stimulation of growth factor receptors such as the insulin-like growth factor-I (IGF-I) receptor.
Adult ovariectomized osteopenic rats were treated with sodium fluoride at a dose of 6 mg/kg per day in drinking water for 8 weeks in association with IGF-I either at a dose of 2 mg/kg per day, which is capable of increasing bone mass, or at a lower dose without detectable skeletal effects.
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11238469 Rosen CJ, Bilezikian JP: Clinical review 123: Anabolic therapy for osteoporosis. . J Clin Endocrinol Metab. 2001 Mar;86(3):957-64.


Fluoride, GH, insulin-like growth factor I, the statins, and PTH will be reviewed.
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