Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
18360603 Maclaughlin EJ, Sleeper RB, McNatty D, Raehl CL: Management of age-related osteoporosis and prevention of associated fractures. Ther Clin Risk Manag. 2006 Sep;2(3):281-95.

Drugs which have been shown to decrease the risk of age-related osteoporotic fractures include oral bisphosphonates (alendronate, ibandronate, and risedronate), intranasal calcitonin, estrogen receptor stimulators (eg, estrogen, selective estrogen receptor modulators [raloxifene]), parathyroid hormone (teriparatide), sodium fluoride, and strontium ranelate.
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19758959 Groheux D, Moretti JL, Giacchetti S, Hindie E, Teyton P, Cuvier C, Bousquet G, Misset JL, Boin C, Espie M: [PET/CT in breast cancer: an update] . Bull Cancer. 2009 Nov;96(11):1053-70.

Roles of new tracers such as F-18 fluoro-L-thymidine (a marker of cell proliferation), 18-fluoro-17-B-estradiol (marker of estrogen receptor) and sodium fluoride (marker of bone matrix) are also mentioned.
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12530170 Dimai HP, Pietschmann P, Resch H, Leb G, Klaushofer K: [Guidelines for drug therapy of postmenopausal osteoporosis] . Wien Med Wochenschr. 2002;152(23-24):596-612.

In Austria, several pharmacologic options for treatment of osteoporosis are available, including bisphosphonates (alendronate, etidronate, risedronate), selective estrogen receptor modulators (raloxifene), calcitonins (salm-calcitonin, elcatonin), fluorides (sodium-fluoride, monofluorophosphate), anabolic steroids (nandrolone-decanoate), steroid derivates (tibolone), estrogen and hormone replacement therapy.
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9689207 Miller P, Lukert B, Broy S, Civitelli R, Fleischmann R, Gagel R, Khosla S, Lucas M, Maricic M, Pacifici R, Recker R, Sarran HS, Short B, Short MJ: Management of postmenopausal osteoporosis for primary care. Menopause. 1998 Summer;5(2):123-31.

RESULTS: Prevention and treatment are discussed, including hormone replacement therapy and use of calcitonin, sodium fluoride, bisphosphonates, and serum estrogen receptor modulators.
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9881322 Netelenbos C: Osteoporosis: intervention options. Maturitas. 1998 Nov 16;30(3):235-9.

During the last 3 years it has become clear that besides estrogen, bisphosphonates and now perhaps the selective estrogen receptor modulators also show a good alternative as intervention option of postmenopausal osteoporosis.
At this moment sodium fluoride is not the first choice in treatment of osteoporosis in general practice.
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12589304 Davidson MR: Pharmacotherapeutics for osteoporosis prevention and treatment. J Midwifery Womens Health. 2003 Jan-Feb;48(1):39-52.


The following effective treatment options for women who have been diagnosed with the disease are discussed: bisphosphonates, calcitonin, and selective estrogen receptor modulators (SERMs).
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11238469 Rosen CJ, Bilezikian JP: Clinical review 123: Anabolic therapy for osteoporosis. . J Clin Endocrinol Metab. 2001 Mar;86(3):957-64.


By acting at this site in the bone remodeling cycle, estrogens, selective estrogen receptor modulators, calcitonin, and the bisphosphonates all have the capacity to increase bone mineral density and to reduce the risk of new fractures.
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