Protein Information

Name TNFalpha
Synonyms Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
12604622 Gogarten W, Lindeman KS, Hirshman CA, Emala CW: Tumor necrosis factor alpha stimulates adenylyl cyclase activity in human myometrial cells. Biol Reprod. 2003 Mar;68(3):751-7.

6(0,0,0,6) Details
11029753 Kozawa O, Yamamoto T, Tanabe K, Akamatsu S, Dohi S, Uematsu T: Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. J Cell Biochem. 2000 Sep 18;80(1):46-52.


Tumor necrosis factor-alpha enhanced the AVP-induced formation of IPs.
1(0,0,0,1) Details
18997433 Nishimoto S, Goto Y, Morishige H, Shiraishi R, Doi M, Akiyama K, Yamauchi S, Sugahara T: Mode of action of the immunostimulatory effect of collagen from jellyfish. Biosci Biotechnol Biochem. 2008 Nov;72(11):2806-14. Epub 2008 Nov 7.

The expression levels of immunoglobulin mRNAs in HB4C5 cells, and those of tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and transforming growth factor (TGF)-beta in hPBL were up-regulated by jellyfish collagen.
This collagen also enhanced IgM production by translation-suppressed HB4C5 cells that had been treated with sodium fluoride, but was ineffective in accelerating IgM production by HB4C5 cells treated with cycloheximide.
1(0,0,0,1) Details
9885886 Bernardin G, Strosberg AD, Bernard A, Mattei M, Marullo S: Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans. Intensive Care Med. 1998 Dec;24(12):1315-22.

We measured beta-adrenergic receptor (betaAR) number and affinity, and intracellular cAMP content at baseline and after the pharmacological stimulation of each component of the beta-adrenergic complex: betaAR with isoproterenol, Gs-protein with sodium fluoride (NaF), adenylate cyclase with forskolin.
Catecholamine (adrenaline, noradrenaline) and cytokine (TNFalpha, IL-1alpha, IL-1beta, IL-6) serum levels were measured.
1(0,0,0,1) Details
9067707 Hamamoto Y, Nagai K, Muto M, Nakamura K, Yasui H, Asagami C: Establishment and characterization of a novel human cell line exhibiting both immunophenotypic markers of monocyte/macrophage and natural killer cell lineages from peripheral blood of a patient with atopic dermatitis. Exp Dermatol. 1997 Feb;6(1):49-53.

The cytochemical staining showed a positive reaction for alpha-naphthyl butyrate esterase, which was completely inhibited by sodium fluoride, but a negative result for periodic acid-Schiff, peroxidase and alkaline phosphatase.
The phorbol ester-stimulated YAA cells produced a considerable amount of tumor necrosis factor-alpha.
1(0,0,0,1) Details
10447558 Hirano S, Ando M, Kanno S: Inflammatory responses of rat alveolar macrophages following exposure to fluoride. Arch Toxicol. 1999 Aug;73(6):310-5.


I.t. instillation of fluoride significantly enhanced mRNA expression of cytokines such as interleukin-1beta (IL-1beta), tumor necrosis factor-alpha, cytokine-induced neutrophil chemoattractant, and macrophage inflammatory proteins-1alpha and -2.
1(0,0,0,1) Details
17903241 Smith N, Browning CA, Duroudier N, Stewart C, Peel S, Swan C, Hall IP, Sayers I: Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus. Respir Res. 2007 Sep 28;8:68.

No treatment significantly influenced sodium fluoride induced IPx responses suggesting regulation occurs at the receptor locus.
Similarly, TNFalpha, IFN gamma or salmeterol treatment augmented bradykinin induced IPx responses (127.4 +/- 8.3, 128.0 +/- 8.4 and 111.7 +/- 5.0%, P < 0.05).
1(0,0,0,1) Details
8915775 Kawase T, Oguro A, Orikasa M, Burns DM: Characteristics of NaF-induced differentiation of HL-60 cells. J Bone Miner Res. 1996 Nov;11(11):1676-87.

Similarly, NaF stimulated the production of interleukin 1 alpha (IL-1 alpha), IL-6, and tumor necrosis factor-alpha, and 1,25 (OH) 2D3 again strongly enhanced these effects.
Sodium fluoride (NaF) is known to stimulate osteoblastic bone formation, but little attention has been given to the possibility that NaF also affects bone resorption and the differentiation of osteoclastic progenitor cells.
1(0,0,0,1) Details
12472997 Mostefaoui Y, Claveau I, Ross G, Rouabhia M: Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices. J Clin Periodontol. 2002 Nov;29(11):1035-41.


Cultured supernatants were used to evaluate cytokine (interleukin (IL)-1beta, IL-8 and tumor necrosis factor (TNF)-alpha) secretion, and metalloproteinase (MMP)-2 and -9 activities.
1(0,0,0,1) Details