Protein Information

Name NTPDase1
Synonyms ATPDase; Hb6; ATPDase; CD39; CD39 antigen; Ecto ATP diphosphohydrolase; Ecto apyrase; Lymphoid cell activation antigen…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
10678111 Yi FX, Liu WL, Chen LW, Zeng S, Guo ZG: Hydrolysis of extracellular adenine nucleotides by cultured bovine endocardial endothelial cells. Zhongguo Yao Li Xue Bao. 1999 Aug;20(8):745-9.


AIM: To characterize the ATP diphosphohydrolase (apyrase) of bovine endocardial endothelial cells, and to compare ecto-adeninenucleotidase activity between bovine endocardial and aortic endothelial cells (BEEC and BAEC).
5(0,0,0,5) Details
15652174 Leal DB, Streher CA, Neu TN, Bittencourt FP, Leal CA, da Silva JE, Morsch VM, Schetinger MR: Characterization of NTPDase (NTPDase1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5) activity in human lymphocytes. Biochim Biophys Acta. 2005 Jan 18;1721(1-3):9-15. Epub 2004 Oct 6.

NTPDase inhibitors, 20 mM sodium fluoride, 0.2 mM trifluoperazine and 0.3 mM suramin, significantly decreased ATP and ADP hydrolysis (P <0.05) and ADP hydrolysis was only inhibited by 0.5 mM orthovanadate (P <0.05).
3(0,0,0,3) Details
8962792 Schetinger MR, Wyse AT, Da Silva LB, Barcellos CK, Dias RD, Sarkis JJ: Effects of aluminum chloride on the kinetics of rat cortex synaptosomal ATP diphosphohydrolase (EC 3.6.1.5). Biol Trace Elem Res. 1995 Dec;50(3):209-19.


The metal ion significantly inhibited ATPase and ADPase activities of the enzyme at all concentrations tested in vitro (0.01, 0.05, 0.5, 5, and 10 mM) in the presence of 1.5 mM calcium.
1(0,0,0,1) Details