Protein Information

Name HRH1
Synonyms H1 R; HRH 1; HRH1; Histamine H1 receptor; Histamine receptor H1; hisH1; Histamine H1 receptors; Histamine receptor H1s…

Compound Information

Name sodium fluoride
CAS sodium fluoride (NaF)

Reference List

PubMed Abstract RScore(About this table)
9884076 Pype JL, Mak JC, Dupont LJ, Verleden GM, Barnes PJ: Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle. Br J Pharmacol. 1998 Dec;125(7):1477-84.

In contrast, the responses to sodium fluoride, a direct G-protein activator, were unalterd by PDBu (100-300 nM) pre-incubation and only slightly reduced following incubation with 1 microM PDBu.
6(0,0,0,6) Details
17903241 Smith N, Browning CA, Duroudier N, Stewart C, Peel S, Swan C, Hall IP, Sayers I: Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus. Respir Res. 2007 Sep 28;8:68.

No treatment significantly influenced sodium fluoride induced IPx responses suggesting regulation occurs at the receptor locus.
H1 Histamine Receptor (HRH1), B2 Bradykinin Receptor (BDKRB2), G alpha q/11 and PLC-beta1 identified that a significant induction of receptor mRNA (> 2 fold) was a feature of these responses explaining the cytokine and spasmogen specificity.
3(0,0,0,3) Details