| Name | protein phosphatase |
|---|---|
| Synonyms | DUSP17; DUSP19; Dual specificity phosphatase 19; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS DSP1; LMW DSP3; Protein phosphatase; Protein phosphatase SKRP1… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9475387 | Eyster KM, Berger TL, Rodrigo MC, Sheth MV: Protein phosphatase activity in the rat ovary throughout pregnancy and pseudopregnancy. Biol Reprod. 1998 Feb;58(2):338-45. Tissues were processed in the presence of sodium fluoride and inorganic to inhibit the phosphatase and thereby prevent autodephosphorylation of the type 2A protein phosphatase (PP2A) during homogenization. |
84(1,1,1,4) | Details |
| 9079918 | McCartney B, Howell LD, Kennelly PJ, Potts M: Protein tyrosine phosphorylation in the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol. 1997 Apr;179(7):2314-8. The P-Tyr content of the three major P-Tyr proteins and several minor proteins increased with their time of incubation in the presence of Mg-ATP and the protein phosphatase inhibitors orthovanadate and sodium fluoride. |
31(0,1,1,1) | Details |
| 17898545 | Ross GR, Yallampalli U, Yallampalli C: Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery. J Vasc Res. 2008;45(1):33-44. Epub 2007 Sep 26. Interestingly, sodium fluoride, a nonspecific protein phosphatase inhibitor, completely blocked the effect of adrenomedullin on CaCl (2)-induced contraction. |
31(0,1,1,1) | Details |
| 12756484 | Gusev GP, Ivanova TI: Activation of Na+/H+ exchange by protein phosphatase inhibitors in red blood cells of the frog Rana ridibunda. J Comp Physiol B. 2003 Jul;173(5):429-35. Epub 2003 May 20. |
6(0,0,0,6) | Details |
| 16875859 | Ivanova TI, Agalakova NI, Gusev GP: Activation of transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A. Comp Biochem Physiol B Biochem Mol Biol. 2006 Sep;145(1):60-7. Epub 2006 Jun 21. |
3(0,0,0,3) | Details |
| 9564854 | Hulley PA, Gordon F, Hough FS: Inhibition of mitogen-activated protein kinase activity and proliferation of an early osteoblast cell line (MBA 15.4) by dexamethasone: role of protein phosphatases. Endocrinology. 1998 May;139(5):2423-31. Because MAPK is inactivated by dephosphorylation of and residues, cells were treated concomitantly for 24 h with dexamethasone and inhibitors of orthovanadate) and/or serine/ phosphatases (sodium fluoride). |
1(0,0,0,1) | Details |
| 8663006 | Rintamaki E, Kettunen R, Aro EM: Differential D1 dephosphorylation in functional and photodamaged photosystem II centers. J Biol Chem. 1996 Jun 21;271(25):14870-5. Degradation of damaged D1 could be prevented even in dim light by sodium fluoride, an inhibitor of protein phosphatases, indicating that dephosphorylation is a prerequisite for D1 proteolysis. Degradation of damaged D1 could be prevented even in dim light by sodium fluoride, an inhibitor of protein phosphatases, indicating that dephosphorylation is a prerequisite for D1 proteolysis. |
2(0,0,0,2) | Details |
| 11440177 | Csapo Z, Sasvari-Szekely M, Spasokoukotskaja T, Staub M: Modulation of human deoxycytidine kinase activity as a response to cellular stress induced by NaF. Acta Biochim Pol. 2001;48(1):251-6. This theory was further investigated using NaF as an inhibitor of protein phosphatases. |
1(0,0,0,1) | Details |
| 10953284 | Haier J, Nicolson GL: Time-dependent dephosphorylation through serine/ phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen. Anticancer Res. 2000 Jul-Aug;20(4):2265-71. In the present study the influence of dephosphorylation by Ser/ protein phosphatases (PPases) on tumor cell adhesion was investigated. Pretreatment of poorly and highly metastatic human HT-29 colon carcinoma cells with the broad-range inhibitors sodium fluoride (NaF) and (PyroP) resulted in strong reduction in adhesion of HT-29 cells to various ECM components. |
1(0,0,0,1) | Details |
| 16808277 | Gusev GP, Ivanova TI: [Protein phosphatases in the regulation of transport across erythrocyte membrane in lamprey, Lampetra fluviatilis] Zh Evol Biokhim Fiziol. 2006 May-Jun;42(3):208-13. |
1(0,0,0,1) | Details |
| 15817783 | Lai SM, Le Moual H: PrpZ, a Salmonella enterica serovar Typhi serine/threonine protein phosphatase 2C with dual substrate specificity. Microbiology. 2005 Apr;151(Pt 4):1159-67. An ORF encoding a polypeptide with homology to protein phosphatases 2C (PP2Cs) was identified in the genomes of Salmonella enterica serovar Typhi strains CT18 and Ty2. Activity of PrpZ (His) was inhibited by EDTA, sodium fluoride, and but unaffected by okadaic acid, indicating that PrpZ is a PP2C. |
1(0,0,0,1) | Details |
| 10321833 | Omura M, Yamaguchi M: Enhancement of neutral phosphatase activity in the cytosol and nuclei of regenerating rat liver: role of endogenous regucalcin. J Cell Biochem. 1999 Jun 1;73(3):332-41. The present study demonstrates that protein phosphatase activity in the cytoplasm and nuclei is enhanced in regenerating rat liver. |
1(0,0,0,1) | Details |
| 9245257 | Douglas P, Pigaglio E, Ferrer A, Halfords NG, MacKintosh C: Three spinach leaf reductase-3-hydroxy-3-methylglutaryl-CoA reductase kinases that are required by reversible phosphorylation and/or Ca2+ ions. Biochem J. 1997 Jul 1;325 ( Pt 1):101-9. PKI was Ca2+-dependent when prepared in the absence of protein phosphatase (PP) inhibitors, and largely Ca2+-dependent when prepared in the presence of PP inhibitors (NaF and EGTA). |
1(0,0,0,1) | Details |
| 12538343 | Chuang SM, Wang IC, Hwua YS, Yang JL: Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis. 2003 Jan;24(1):7-15. Intriguingly, sodium fluoride or okadaic acid, inhibitors for serine/threonine protein phosphatases (PP), recovered the JNK activity in CL3 cells exposed to Cd plus 3AT; however, the protein tyrosine phosphatases inhibitor orthovanadate did not. |
1(0,0,0,1) | Details |
| 16414982 | Bogatcheva NV, Wang P, Birukova AA, Verin AD, Garcia JG: Mechanism of -induced MAP kinase activation in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1139-45. Epub 2006 Jan 13. In this study, we demonstrate that challenge of endothelial cells (EC) with NaF, a recognized G protein activator and protein phosphatase inhibitor, leads to a significant Erk activation, with increased phosphorylation of the well-known Erk substrate caldesmon. |
1(0,0,0,1) | Details |
| 14710095 | Sugiyama M, Imai A, Furui T, Tamaya T: Membrane-associated serine/threonine protein phosphatase in endometrial cancer. Am J Obstet Gynecol. 2003 Dec;189(6):1666-9. We attempted to determine the subcellular location of serine/ phosphatase (protein phosphatase type 2A [PP2A]) in endometrial cancer. The membrane phosphatase was sensitive to inhibition by okadaic acid and sodium fluoride, characteristics suggestive of PP2A activity. |
1(0,0,0,1) | Details |
| 10462480 | Banerjee-Bhatnagar N: Inorganic regulates CryIVA protoxin expression in Bacillus thuringiensis israelensis. Biochem Biophys Res Commun. 1999 Aug 27;262(2):359-64. Addition of protein phosphatase inhibitors NaF and calyculin A during resuspension resulted in the inhibition of toxin synthesis by Bti cells. |
1(0,0,0,1) | Details |
| 17899011 | Furuhashi K: Alkaline phosphatase of Physarum polycephalum is insoluble. Arch Microbiol. 2008 Feb;189(2):151-6. Epub 2007 Sep 26. Some phosphatases including protein phosphatase and acid phosphatase have been purified from the plasmodia, but alkaline phosphatase remains to be elucidated. |
1(0,0,0,1) | Details |
| 8900457 | Lau TE, Rodriguez MA: A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase. Lipids. 1996 Mar;31(3):277-83. A crude protein phosphatase preparation from liver was capable of reversing the effects of both activities. |
1(0,0,0,1) | Details |
| 11494123 | Jaumot M, Hancock JF: Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene. 2001 Jul 5;20(30):3949-58. General serine- phosphatase inhibitors such sodium fluoride, or ss-glycerophosphate and or specific PP1 and PP2A inhibitors including microcystin-LR, protein phosphatase 2A inhibitor I (1) or protein phosphatase inhibitor 2 all abrogate H-Ras and K-Ras dependent Raf-1 activation in vitro. |
1(0,0,0,1) | Details |
| 10888470 | Kovacs P, Csaba G: Fluorimetric analysis of phospholipase activity in Tetrahymena pyriformis GL. Biosci Rep. 1999 Apr;19(2):81-7. The phospholipase A2 inhibitor, quinacrine, and the protein phosphatase inhibitor, neomycin, inhibited the enzyme activity in vitro and activated it in vivo. |
1(0,0,0,1) | Details |
| 15075332 | Hashigasako A, Machide M, Nakamura T, Matsumoto K, Nakamura T: Bi-directional regulation of Ser-985 phosphorylation of c-met via protein kinase C and protein phosphatase 2A involves c-Met activation and cellular responsiveness to hepatocyte growth factor. J Biol Chem. 2004 Jun 18;279(25):26445-52. Epub 2004 Apr 9. Likewise, treatment of cells with NaF (an inhibitor of protein phosphatases) allowed for phosphorylation of Ser-985, and a protein phosphatase responsible for dephosphorylation of Ser-985 was identified to be protein phosphatase 2A (PP2A). |
1(0,0,0,1) | Details |
| 12507602 | Agalakova NI, Gusev GP: Effect of protein kinase C activation on Na+-H+ exchange in erythrocytes of frog Rana temporaria. Comp Biochem Physiol A Mol Integr Physiol. 2003 Jan;134(1):11-20. Pretreatment of frog red blood cells for 5, 10 or 15 min with 10 mM NaF, non-selective inhibitor of protein phosphatase, led to a progressive stimulation of the PMA effect on Na (+) influx. |
1(0,0,0,1) | Details |