Protein Information

Name glycine receptor (protein family or complex)
Synonyms Glycine receptor; Glycine receptors

Compound Information

Name chloralose
CAS

Reference List

PubMed Abstract RScore(About this table)
10683198 Krasowski MD, Harrison NL: The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations. Br J Pharmacol. 2000 Feb;129(4):731-43.

For all anaesthetics studied except alpha-chloralose, at least one of the mutations above abolished drug potentiation of agonist responses at GABA (A) and glycine receptors. alpha-Chloralose produced efficacious direct activation of the GABA (A) alpha (2) beta (1) receptor (a 'GABA-mimetic' effect).
84(1,1,1,4) Details
9121816 Sorkin LS, Puig S: Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain. 1996 Dec;68(2-3):283-92.

In this study, we sought to characterize the effect of focal glycine-receptor inhibition on spontaneous and evoked activity in dorsal horn neurons of the chloralose-anesthetized cat.
81(1,1,1,1) Details
18597935 Wang K, Zheng C, Wu C, Gao M, Liu Q, Yang K, Ellsworth K, Xu L, Wu J: alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices. Neurosci Lett. 2008 Aug 15;441(1):66-71. Epub 2008 Jun 8.

It is concluded that alpha-chloralose suppresses hippocampal gamma oscillations without significantly affecting basic synaptic transmission or ionotropic glutamate, choline and glycine receptor function.
81(1,1,1,1) Details
9766836 Sorkin LS, Puig S, Jones DL: Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists. Pain. 1998 Aug;77(2):181-90.

In this study, we sought to characterize the effects of focal GABA (A) receptor antagonism on spontaneous and evoked activity in dorsal horn neurons of the alpha-chloralose anesthetized cat.
This is in contrast to our previous work with glycine receptor antagonism where only the evoked response to hair follicle activation was significantly enhanced.
1(0,0,0,1) Details