| Name | Inorganic pyrophosphatase |
|---|---|
| Synonyms | Cytosolic inorganic pyrophosphatase; IOPPP; Inorganic pyrophosphatase; Inorganic pyrophosphatase 1; PP; PP1; PPA 1; PPA1… |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12823552 | Islam MK, Miyoshi T, Kasuga-Aoki H, Isobe T, Arakawa T, Matsumoto Y, Tsuji N: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites. Eur J Biochem. 2003 Jul;270(13):2814-26. We observed that native PPase activity together with development and molting in vitro of A. suum L3 to L4 were efficiently inhibited in a dose-dependent manner by imidodiphosphate and sodium fluoride, which are potent inhibitor of both soluble- and membrane-bound H+-PPases. |
88(1,1,1,8) | Details |
| 9806759 | Martin F, Pintor J, Rovira JM, Ripoll C, Miras-Portugal MT, Soria B: Intracellular diadenosine polyphosphates: a novel second messenger in stimulus-secretion coupling. FASEB J. 1998 Nov;12(14):1499-506. Inorganic pyrophosphatase inhibition with sodium fluoride blocks 22 mM -induced [ApnA] i increase. |
82(1,1,1,2) | Details |
| 15760657 | Soares Medeiros LC, Moreira BL, Miranda K, de Souza W, Plattner H, Hentschel J, Barrabin H: A pumping pyrophosphatase in acidocalcisomes of Herpetomonas sp. Mol Biochem Parasitol. 2005 Apr;140(2):175-82. Epub 2005 Jan 19. This uptake has an optimal pH of 6.5-6.7 and was inhibited by sodium fluoride (NaF) and imidodiphosphate (IDP), two H+-pyrophosphatase inhibitors. |
34(0,1,1,4) | Details |
| 12151384 | Peters MA, Jackson DC, Crabb BS, Browning GF: Chicken anemia virus VP2 is a novel dual specificity protein phosphatase. . J Biol Chem. 2002 Oct 18;277(42):39566-73. Epub 2002 Jul 31. Both CAV GST-VP2 and TLMV GST-ORF2 fusion proteins possessed S/T PPase activity, which was specifically inhibited by 50 mm sodium fluoride. |
34(0,1,1,4) | Details |
| 11373080 | Eriksson J, Karamohamed S, Nyren P: Method for real-time detection of inorganic pyrophosphatase activity. Anal Biochem. 2001 Jun 1;293(1):67-70. |
8(0,0,0,8) | Details |
| 11009607 | Baykov AA, Fabrichniy IP, Pohjanjoki P, Zyryanov AB, Lahti R: effects along the reaction pathway of pyrophosphatase: evidence for a second enzyme.pyrophosphate intermediate. Biochemistry. 2000 Oct 3;39(39):11939-47. |
7(0,0,0,7) | Details |
| 16243777 | Jeon SJ, Ishikawa K: Characterization of the Family I inorganic pyrophosphatase from Pyrococcus horikoshii OT3. Archaea. 2005 Dec;1(6):385-9. |
5(0,0,0,5) | Details |
| 9784495 | Gdula DA, Sandaltzopoulos R, Tsukiyama T, Ossipow V, Wu C: Inorganic pyrophosphatase is a component of the Drosophila nucleosome remodeling factor complex. Genes Dev. 1998 Oct 15;12(20):3206-16. Inhibition of the pyrophosphatase activity of NURF with sodium fluoride has no significant effect on chromatin remodeling, indicating that these two activities may be biochemically uncoupled. |
4(0,0,0,4) | Details |
| 12669192 | Celis H, Franco B, Escobedo S, Romero I: Rhodobacter sphaeroides has a family II pyrophosphatase: comparison with other species of photosynthetic bacteria. Arch Microbiol. 2003 May;179(5):368-76. Epub 2003 Apr 1. |
4(0,0,0,4) | Details |
| 10898947 | Kuhn NJ, Wadeson A, Ward S, Young TW: Methanococcus jannaschii ORF mj0608 codes for a class C inorganic pyrophosphatase protected by Co (2+) or Mn (2+) ions against inhibition. Arch Biochem Biophys. 2000 Jul 15;379(2):292-8. However, prior exposure to these ions afforded striking protection against inhibition by sodium fluoride, to which the enzyme was otherwise very sensitive. |
3(0,0,0,3) | Details |
| 11068824 | Bonting CF, Gerards R, Zehnder AJ, Kortstee GJ: Purification and properties of pyrophosphatase of Acinetobacter johnsonii 210A and its involvement in the degradation of polyphosphate. Biodegradation. 1999;10(6):393-8. |
3(0,0,0,3) | Details |
| 10727425 | Marchesini N, Luo S, Rodrigues CO, Moreno SN, Docampo R: Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites. Biochem J. 2000 Apr 1;347 Pt 1:243-53. PP (i) hydrolysis was sensitive in a dose-dependent manner to AMDP, imidodiphosphate, sodium fluoride, dicyclohexylcarbodi-imide and to the thiol reagent, N-ethylmaleimide. |
3(0,0,0,3) | Details |
| 10187907 | Avaeva SM, Velichko TI, Vorobyeva NN, Kurilova SA, Nazarova TI, Sklyankina VA: Stabilization of the enzyme--substrate complex of the mutant Asp-67Asn inorganic pyrophosphatase from Escherichia coli by ions. Biochemistry. 1999 Feb;64(2):169-74. |
2(0,0,0,2) | Details |
| 15135060 | Schulze S, Mant A, Kossmann J, Lloyd JR: Identification of an Arabidopsis inorganic pyrophosphatase capable of being imported into chloroplasts. FEBS Lett. 2004 May 7;565(1-3):101-5. |
2(0,0,0,2) | Details |
| 9143364 | Hiraishi H, Ohmagari T, Otsuka Y, Yokoi F, Kumon A: Purification and characterization of hepatic inorganic pyrophosphatase hydrolyzing imidodiphosphate. Arch Biochem Biophys. 1997 May 1;341(1):153-9. This hydrolase required divalent cations such as MgCl2, CoCl2, and MnCl2 to hydrolyze and was insensitive to 2 mM sodium fluoride. |
2(0,0,0,2) | Details |
| 10953284 | Haier J, Nicolson GL: Time-dependent dephosphorylation through serine/ phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen. Anticancer Res. 2000 Jul-Aug;20(4):2265-71. In the present study the influence of dephosphorylation by Ser/ protein phosphatases (PPases) on tumor cell adhesion was investigated. Pretreatment of poorly and highly metastatic human HT-29 colon carcinoma cells with the broad-range inhibitors sodium fluoride (NaF) and (PyroP) resulted in strong reduction in adhesion of HT-29 cells to various ECM components. |
1(0,0,0,1) | Details |
| 10762652 | Courtois P, Louchami K, Laghmich A, Picton S, Jijakli H, Sener A, Malaisse WJ: Possible role of diadenosine polyphosphates in -stimulated insulin release: effects of NaF upon metabolic and functional variables in rat isolated islets. Int J Mol Med. 2000 May;5(5):493-503. Since NaF, an inhibitor of inorganic pyrophosphatase, was reported to lower A2P3 and A2P4 content in -stimulated pancreatic islets, its effects upon metabolic, cationic, biosynthetic and secretory variables in rat pancreatic islets were investigated in the present study. |
1(0,0,0,1) | Details |
| 16959050 | Islam MK, Miyoshi T, Yamada M, Alim MA, Huang X, Motobu M, Tsuji N: exposure inhibits protein expression and enzyme activity in the lung-stage larvae of Ascaris suum. Parasitology. 2006 Oct;133(Pt 4):497-508. Sodium fluoride (NaF) is an anion that has been previously shown to block the moulting process of Ascaris suum larvae. Enzyme assay and immunochemical data showed an inhibition of the moulting-specific inorganic pyrophosphatase activity by 41% and a decreased expression in NaF-treated larvae, indicating its significance in the moulting process. |
1(0,0,0,1) | Details |