| Name | acetylcholine receptor (protein family or complex) |
|---|---|
| Synonyms | Acetylcholine receptor; Acetylcholine receptors |
| Name | sodium fluoride |
|---|---|
| CAS | sodium fluoride (NaF) |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19900517 | Liu YJ, Gao Q, Wu CX, Guan ZZ: Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory. Toxicol Lett. 2010 Feb 15;192(3):324-9. Epub 2009 Nov 10. In order to reveal the mechanism of the decreased ability of learning and memory induced by chronic fluorosis, nicotinic acetylcholine receptors (nAChRs) and the pathway of extracellular signal regulated protein kinase (ERK1/2) were investigated by using the rats fed with different concentrations of sodium fluoride for 6 months. |
31(0,1,1,1) | Details |
| 12504354 | Chen J, Shan KR, Long YG, Wang YN, Nordberg A, Guan ZZ: Selective decreases of nicotinic acetylcholine receptors in PC12 cells exposed to Toxicology. 2003 Feb 1;183(1-3):235-42. |
2(0,0,0,2) | Details |
| 12126925 | Zhao W, Rouatbi S, Tabka Z, Guenard H: Inhaled sodium fluoride decreases airway responsiveness to analogs in vivo. Respir Physiol Neurobiol. 2002 Aug 1;131(3):245-53. The study was conducted to characterize the action of NaF, which had relaxing property in carbachol precontracted isolated bovine bronchus, on airway responsiveness challenged by acetylcholine receptor agonists in rats and asthmatic humans. |
1(0,0,0,1) | Details |
| 15107774 | Giachini M, Pierleoni F: toxicity] . Minerva Stomatol. 2004 Apr;53(4):171-7. Moreover, sodium-fluoride may cause adverse effects on testicular activity (connected to oxidative-stress depending on increased activity of peroxidases and catalases) due to inhibition of 2 androgenesis-regulator enzymes DELTA (5) b-HSD and 17beta-HSD. At encephalic level, then, high doses of cause the onset of neurological symptoms and of a decreased spontaneous motor activity due to a reduction in the number of nicotinic acetylcholine receptors. |
1(0,0,0,1) | Details |
| 18282683 | Gao Q, Liu YJ, Guan ZZ: Oxidative stress might be a mechanism connected with the decreased alpha 7 nicotinic receptor influenced by high-concentration of in SH-SY5Y neuroblastoma cells. Toxicol In Vitro. 2008 Jun;22(4):837-43. Epub 2008 Jan 15. The possible mechanism concerning decreased alpha 7 nicotinic acetylcholine receptor (nAChR) influenced by fluorosis was investigated. |
1(0,0,0,1) | Details |